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The inhibitory responses to glycine, taurine, beta-alanine, 2-amino-5-phosphonovaleric acid (APV) were investigated in freshly isolated neurones from medulla oblongata and hippocampus of rat using concentration clamp, voltage clamp and intracellular perfusion techniques. All substances, when applied in a steplike manner, induced a rapid increase in the(More)
Prolonged exposure of hippocampal slices to L-glutamate was found to produce a biphasic effect on excitatory synaptic transmission from Schaffer collateral-commissural fibers to CA1 pyramidal neurons: an early blockade of postsynaptic responses was followed by a progressive recovery. Antagonists of N-methyl-D-aspartate (NMDA) receptors, which had no effect(More)
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