Oscar Julian Booker

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BACKGROUND Regadenoson, dipyridamole and adenosine are commonly used vasodilators in myocardial perfusion imaging for the detection of obstructive coronary artery disease. There are few comparative studies of the vasodilator properties of regadenoson, adenosine and dipyridamole in humans. The specific aim of this study was to determine the relative potency(More)
BACKGROUND Myocardial infarction (MI) documented by late gadolinium enhancement (LGE) has clinical and prognostic importance, but its detection is sometimes compromised by poor contrast between blood and MI. MultiContrast Delayed Enhancement (MCODE) is a technique that helps discriminate subendocardial MI from blood pool by simultaneously providing a(More)
BACKGROUND Observational studies show that glucocorticoid therapy and the endogenous hypercortisolism of Cushing's syndrome (CS) are associated with increased rates of cardiovascular morbidity and mortality. However, the causes of these findings remain largely unknown. OBJECTIVE To determine whether CS patients have increased coronary atherosclerosis. (More)
Ebstein's anomaly is a complex congenital lesion which primarily involves the tricuspid valve. The tricuspid leaflets are tethered to varying degrees to the right ventricular free wall and the ventricular septum often resulting in significant tricuspid regurgitation and a small functioning right ventricular chamber. Although the septal leaflet originates(More)
Vasodilator stress cardiac magnetic resonance (CMR) detects ischemia whereas coronary CT angiography (CTA) detects atherosclerosis. The purpose of this study was to determine concordance and accuracy of vasodilator stress CMR and coronary CTA in the same subjects. We studied 151 consecutive subjects referred to detect or exclude suspected obstructive(More)
Methods Dogs (n=10) underwent coronary occlusion (2h) and reperfusion (4h). 1.5T CMR images (Siemens) were taken before and 45 minutes into contrast administration (0.15mmol/kg Gd-DTPA bolus followed by 0.003mmol/kg/min infusion). Myocardial T1 was measured by modified Look-Locker imaging (MOLLI), infarction by late gadolinium enhancement (LGE) imaging, and(More)
Methods Dogs (n=9) underwent coronary occlusion and reperfusion to delineate the time course of development of changes in non-contrast T1 abnormalities. T1 was quantified by 1.5T CMR (Siemens) using a Modified LookLocker Inversion Recovery (MOLLI) sequence. T2prepared SSFP (T2p) and LGE images were acquired at the end of the experiment to define 1)(More)
Introduction Quantitative myocardial perfusion to assess impaired coronary vasoreactivity has been used to identify subclinical atherosclerosis. Impaired coronary vasodilation has been observed in patients with cardiac risk factors in the MESA cohort. The coronary vasodilator response in patients with angiographically normal coronary arteries/ minimal(More)
BACKGROUND Transcatheter aortic valve replacement (TAVR) was FDA approved for the Sapien valve (Edwards Lifesciences) in the United States in November 2011. We sought to examine the impact of TAVR post-FDA approval on aortic valve surgery at our institution. STUDY DESIGN Prospective data were collected on 573 consecutive patients that underwent surgical(More)