Oscar Diaz Horta

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PURPOSE Autosomal recessive nonsyndromic deafness (ARNSD) is characterized by a high degree of genetic heterogeneity, with reported mutations in 58 different genes. This study was designed to detect deafness-causing variants in a multiethnic cohort with ARNSD by using whole-exome sequencing (WES). METHODS After excluding mutations in the most common gene,(More)
In response to glucose, mouse beta-cells display slow oscillations of the membrane potential and cytosolic free Ca(2+) concentration ([Ca(2+)](i)), whereas rat beta-cells display a staircase increase in these parameters. Mouse and rat islet cells differ also by their level of Na/Ca exchanger (NCX) activity. The view that the inward current generated by(More)
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