Learn More
We propose two scheduling and resource allocation schemes that deal with Quality of Service (QoS) requirements in Uplink Long Term Evolution (LTE) systems. QoS for a multiclass system has been seldom taken into account in previous resource allocation algorithms for LTE uplink. In one of the new algorithms, we investigate the possibility of assigning more(More)
The eukaryotic translation elongation factor eIF5A is the only protein known to contain the unusual amino acid hypusine which is essential for its biological activity. This post-translational modification is achieved by the sequential action of the enzymes deoxyhypusine synthase (DHS) and deoxyhypusine hydroxylase (DOHH). The crucial molecular function of(More)
There are no specific treatments for the neurological alterations of cirrhotic patients with minimal hepatic encephalopathy (MHE). Rats with MHE due to portacaval shunt (PCS) show impaired spatial learning. The underlying mechanisms remain unknown. The aims of this work were to assess: (a) whether PCS rats show neuroinflammation in hippocampus, (b) whether(More)
The paper introduces a novel problem based on causal modeling in marketing where knowledge discovery is able to provide useful results (as shown in a real-world application). The problem features (with uncertain data and available expert knowledge) and the proposed multiobjective optimization approach makes genetic fuzzy systems to be a good framework to(More)
In this paper, we investigate the problem of schedulingand resource allocation for LTE Single Cell Uplink systemswhich use Single Carrier Frequency Division MultipleAccess (SC-FDMA). SC-FDMA (L-FDMA scheme) has particularscheduling requirements such as limited power consumption and contiguous resource block constraints. This last requirement has been seldom(More)
1,4-Oxazines are presented, which show good in vitro inhibition in enzymatic and cellular BACE1 assays. We describe lead optimization focused on reducing the amidine pKa while optimizing interactions in the BACE1 active site. Our strategy permitted modulation of properties such as permeation and especially P-glycoprotein efflux. This led to compounds which(More)
Content-Centric Networking (CCN) is a recently proposed networking architecture that can potentially lead to reduced bandwidth usage and better scalability and security as compared to the current IP-based architecture. In this paper, we conduct an energy consumption analysis of content-centric networking and IP-based networking for a video streaming(More)
Aminopiperazinone inhibitors of BACE were identified by rational design. Structure based design guided idea prioritization and initial racemic hit 18a showed good activity. Modification in decoration and chiral separation resulted in the 40 nM inhibitor, (-)-37, which showed in vivo reduction of amyloid beta peptides. The crystal structure of 18a showed a(More)
We report the continuation of a focused medicinal chemistry program aimed to further optimize a series of imidazo[1,2-a]pyrazines as a novel class of potent and selective phosphodiesterase 10A (PDE10A) inhibitors. In vitro and in vivo pharmacokinetic and pharmacodynamic evaluation allowed the selection of compound 25a for its assessment in preclinical(More)