Oscar Días

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This article describes Merlin, a user-friendly program that performs functional genomic annotations of lists of genes. Merlin retrieves information of each homologue and automatically scores the results, allowing the user to change the score selection, and dynamically (re-)annotate the genome. Merlin expedites the transition from genome-scale data to SBML(More)
The Metabolic Models Reconstruction Using Genome-Scale Information (merlin) tool is a user-friendly Java application that aids the reconstruction of genome-scale metabolic models for any organism that has its genome sequenced. It performs the major steps of the reconstruction process, including the functional genomic annotation of the whole genome and(More)
Even before having its genome sequence published in 2004, Kluyveromyces lactis had long been considered a model organism for studies in genetics and physiology. Research on Kluyveromyces lactis is quite advanced and this yeast species is one of the few with which it is possible to perform formal genetic analysis. Nevertheless, until now, no complete(More)
Mutations in GJB2 gene (encoding connexin 26) are the most common cause of hereditary non-syndromic sensorineural hearing loss (NSSHL) in different populations. The majority of GJB2 mutations are recessive, but a few dominant mutations have been associated with hearing loss either isolated or associated with skin disease. We describe a novel dominant(More)
Genome-scale model reconstruction represents a major tool in the field of Metabolic Engineering .This paper reports on a study about data integration issues in the process of ge-nome-scale reconstruction of the metabolic model of the bacterium Zymomonas mobilis, a promising organism for bioethanol production. Data is retrieved from the Entrez Gene, KEGG,(More)
Ashbya gossypii is an industrially relevant microorganism traditionally used for riboflavin production. Despite the high gene homology and gene order conservation comparatively with Saccharomyces cerevisiae, it presents a lower level of genomic complexity. Its type of growth, placing it among filamentous fungi, questions how close it really is from the(More)
Usually, transport reactions are added to genome-scale metabolic models (GSMMs) based on experimental data and literature. This approach does not allow associating specific genes with transport reactions, which impairs the ability of the model to predict effects of gene deletions. Novel methods for systematic genome-wide transporter functional annotation(More)
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