Oscar Berlanga

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Heavy light chain (HLC) assays allow precise measurement of the monoclonal and of the noninvolved polyclonal immunoglobulins of the same isotype as the M-protein (e.g., monoclonal IgAκ and polyclonal IgAλ in case of an IgAκ myeloma), which was not possible before. The noninvolved polyclonal immunoglobulin is termed 'HLC-matched pair'. We investigated the(More)
The recent publication by Kim et al. [1] compares the performance of two serum free light chain (sFLC) assays, the polyclonal antibody based Freelite and the monoclonal antibody based N-Latex-FLC. We welcome the opportunity to comment on the design of the study and interpretation of results. Serum and urine electrophoresis can be used to identify monoclonal(More)
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