Osanni Nikaido

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To assess regulatory mechanism(s) of hormone production between ectopic and eutopic tumor cells, the effect of sodium butyrate on cell growth and hormone production was studied in BeWo, a trophoblastic cell line and in HeLa S3, a nontrophoblastic cell line. The addition of 2 mM sodium butyrate to HeLa S3 produced a marked increase in hCG-alpha both in the(More)
There is ample epidemiological evidence showing that sunlight can cause skin cancer in the human. In experimental studies, simulated sunlight or UV lamps are used for demonstrating carcinogenesis and other biological effects. Little studies, however, have been performed using natural sunlight itself. In this work, we have examined the mutagenicity of(More)
Do host cell repair processes affect the mutagenesis of UV-irradiated virus in human cells? The answer was obtained by investigating the mutagenesis of UV-irradiated herpes simplex virus after the irradiated virus was grown in human cells that possess normal repair capacity (normal) or lack excision repair (XPA) or post-replication repair (XP var). Evidence(More)
The frequency of surviving colonies in two V79 cell lines exposed to either 6-thioguanine or 8-azaguanine was dependent on initial plating density. Different degrees of metabolic-co-operation were found to occur in the two cell lines and the loss of both spontaneous and added mutants occurred at a lower cell density when 6TG was used for selection than when(More)
To understand the heterogeneity in genetic predisposition to skin can cer in different nucleotide excision repair-deficient human syndromes, we studied repair of cyclobutane pyrimidine dimers (CPDs) and of pyrimidine(6-4)pyrimidone (6-4PP) photoproducts in cells from trichothiodystrophy (TTD) patients. Ill) is not associated with increased incidence of skin(More)
Immunocytochemistry was used for the direct measurement of cyclobutane pyrimidine dimers, (6-4) photoproducts, and Dewar ¡sinnersin nor mal human mononuclear cells following irradiation by natural sunlight or by a FS20 broad spectrum UVB sunlamp. The induction of each type of photoproduct was detected following 30-60 min sunlight exposure or with FS20(More)
To assess regulatory mechanism(s) of hormone production between ectopic and eutopic tumor cells, the effect of sodium butyrate on cell growth and hormone production was studied in BeWo, a trophoblastic cell line and in HeLa S3, a nontrophoblastic cell line. The addition of 2 mM sodium butyrate to HeLa S3 produced a marked increase in hCG-α both in the(More)
We introduced two mutant genes (beige; bg that induces the deficiency of natural killer (NK) activity andxid that decreases the production of immunoglobulin) into KSN nude mice with high reproductive performances. We produced KSNbg/bg(nu/nu) (KSN-bg), KSN-xid/xid(nu/nn) (KSN-xid), KSNxid/xid;bg/bg(nu/nu) (KSN-BNX) and KSN-nu/+ (KS) mice by backcross(More)
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