Osamu Komiyama

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We searched hop extract for active component(s) that inhibited bone resorption in the pit formation assay, and isolated xanthohumol and humulone as active ingredients. Especially humulone had extraordinarily strong inhibitory activity and the IC50 (concentration of 50% inhibition) value was 5.9 x 10(-9)M.
OBJECTIVE The present study evaluated ethnic differences in sensory, pain responses, and the exteroceptive suppression reflex (ES) in the trigeminal region. METHODS Twenty-eight Caucasian (14 men and 14 women, age from 20 to 31) and 28 gender and age matched Japanese participated. Tactile detection thresholds and filament-prick pain detection thresholds(More)
UNLABELLED The aim of the present study was to evaluate ethnic differences of the tactile detection threshold (TDT), the filament-prick pain detection threshold (FPT), the pressure pain detection threshold (PPT), and the pressure pain tolerance detection threshold (PTOL) in the orofacial region of symptom-free subjects. Twenty-two men and 22 women in(More)
AIMS To assess the hypothesis that an additional intravenous gammaglobulin (IVGG) infusion, if administered early, may prevent coronary artery lesions (CAL) in patients with Kawasaki disease (KD) who do not respond to initial IVGG therapy. METHODS Forty four KD patients (17 with CAL and 27 without CAL), treated with additional IVGG because of persistent(More)
The aim of the present study was to evaluate the tactile detection threshold (TDT), the filament-prick pain detection threshold (FPT), the pressure pain threshold (PPT), and the pressure pain tolerance detection threshold (PTOL) at multiple measuring points in the orofacial region of normal subjects. Sixteen males and 16 females (age range from 20 to 41(More)
STATEMENT OF PROBLEM The selective pressure technique has been recommended for making impressions of maxillary edentulous residual ridges. Although various methods for making impressions have been reported, a definitive procedure has not been clearly elucidated. PURPOSE This in vitro study evaluated changes in impression pressure produced by different(More)
Using functional magnetic resonance imaging (fMRI), we compared the cerebral activity during bilateral light fist-clenching and light-teeth clenching to provide more information on the central processing mechanisms underlying awake bruxism. Fourteen subjects participated in our study. Statistical comparisons were used to identify brain regions with(More)
OBJECTIVE This study examined the somatosensory function in the trigeminal region and quantitative measures of the exteroceptive suppression (ES) period in the masseteric EMG, in relation to a psychological evaluation. METHODS The ES in the surface EMG was recorded from the left masseter muscle in 12 men and 12 women. The stimulation intensity at which(More)
The exact mechanism underlying chronic masseter muscle pain, a conspicuous symptom in temporomandibular disorder, remains unclear. We investigated whether expression of P2X3 receptor (P2X3R) is involved in mechanical hyperalgesia after contraction of masseter muscle (CMM). As compared with sham rats, the head-withdrawal threshold (HWT) to mechanical(More)
AIMS To clarify the effects of experimental trapezius muscle pain on the spread of pain and on jaw motor function. METHODS In 12 male subjects aged 25 to 35 years, experimental pain was induced in the superior border of the trapezius muscle by injecting 0.5 mL of hypertonic (6%) saline. The control infusion consisted of a 0.5-mL isotonic (0.9%) saline(More)