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An O-glycoside of sialic acid derivative that inhibits both hemagglutinin and sialidase activities of influenza viruses.
The experimental results indicate that compound 4 not only inhibits the attachment of virus to the cell surface receptor but also disturbs the release of the progeny viruses from infected cells by inhibiting both hemagglutinin and sialidase of the influenza viruses. Expand
Glycan structure and site of glycosylation in the ER-resident glycoprotein, uridine 5'-diphosphate-glucose: glycoprotein glucosyltransferases 1 from rat, porcine, bovine, and human.
The site of glycosylation and the glycan structures in UGGT1 are revealed and their position of attachment to a carrier protein, uridine 5'-diphosphate-glucose: glycoprotein glucosyltransferase (UGGT1), as detected using tandem mass spectrometry. Expand
Glycosylation Using Methylthioglycosides of N-Acetylneuraminic Acid and Dimethyl(Methylthio)Sulfonium Triflate
Abstract Recently, great interest has been focussed on the synthesis of oligosaccharides containing N-acetylneuraminic acid (Neu5Ac) because of its important roles in a variety of biologicalExpand
Syntheses of C‐3‐Modified Sialylglycosides as Selective Inhibitors of Influenza Hemagglutinin and Neuraminidase
In an effort to develop new structures as inhibitors of both influenza virus proteins hemagglutinin and neuraminidase, a series of sialic acid derivatives, including those with one of the hydrogenExpand
Synthesis and enzymatic evaluation of five-membered iminocyclitols and a pseudodisaccharide.
The synthesis of five-membered iminocyclitols with galacto-configuration and a pseudodisaccharide is described, and their inhibitory activities against beta-galactosyltransferase, beta-Galactosidase and alpha-mannosidases are described. Expand
A trisaccharide acceptor analog for N-acetylglucosaminyltransferase V which binds to the enzyme but sterically precludes the transfer reaction.
This is the first example of a glycosyltransferase acceptor analog in which strategic replacement of a nonreacting hydroxyl group with a larger substituent produces a molecule which is recognized by the enzyme but does not react because of a steric block to the Glycosyl transfer reaction. Expand
Towards oligosaccharide libraries: a study of the random galactosylation of unprotected N-acetylglucosamine.
Results suggest 'random-glycosylation' to be a valid strategy for the rapid production of oligosaccharide libraries. Expand
6SLN-lipo PGA specifically catches (coats) human influenza virus and synergizes neuraminidase-targeting drugs for human influenza therapeutic potential.
6SLN-lipo PGA is a new potential candidate drug for influenza control and is an attractive candidate for use in combination with an NAI drug for minimized toxicity, delayed development of resistance, prevention and treatment with the potential for eradication of human influenza. Expand
Non-enzymatic reaction of glycosyl oxazoline with peptides.
This work made an attempt to identify the side product of the oxazoline ring was attacked by the amino group of lysine, leading to the formation of disubstituted acetamidine by using model substrates. Expand
Pd Nanoparticles
Osamu Kanie, Mitsubishi Kagaku Institute of Life Sciences (MITILS), Japan (Original Commentary) Chi-Huey Wong, The Scripps Research Institute, USA (Original Commentary) Roser Pleixats, UniversitatExpand