Orly Vardeny

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Neprilysin is an enzyme that contributes to the breakdown of the biologically active natriuretic peptides and several other vasoactive compounds. Inhibiting neprilysin has been a therapeutic target for several compounds that have been tested in cardiovascular disease, including ecadotril, candoxatril, omapatrilat, and LCZ696. Although ecadotril,(More)
STUDY OBJECTIVE To determine whether T-cell immune responses to influenza vaccination in patients with chronic heart failure (CHF) are less vigorous than the responses of healthy control subjects. DESIGN Prospective, single-center study. SETTING University hospital and research laboratory. PARTICIPANTS Eighteen adults with stable CHF receiving optimal(More)
AIMS In this analysis, we utilized data from PARADIGM-HF to test the hypothesis that participants who exhibited any dose reduction during the trial would have similar benefits from lower doses of sacubitril/valsartan relative to lower doses of enalapril. METHODS AND RESULTS In a post-hoc analysis from PARADIGM-HF, we characterized patients by whether they(More)
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