Orlando daSilva

Learn More
OBJECTIVE The aim of this study was to test the null hypothesis that size at birth relative to fetal or neonatal growth standards is not a significant variable related to the risk of spontaneous preterm delivery. STUDY DESIGN This was a hospital-based cohort study of consecutive births at a tertiary care perinatal center from January 1, 1985, to December(More)
OBJECTIVE The purpose of this study was to further delineate the impact of preterm chorioamnionitis on a spectrum of neonatal outcomes using a large tertiary hospital population. STUDY DESIGN The perinatal/neonatal and placental pathology databases of St. Joseph's Health Care, London, Ontario, Canada, were used to obtain the umbilical cord gas and pH(More)
PURPOSE To determine whether mutations in the FZD4 gene are a risk factor for developing severe ROP. METHODS Three Canadian tertiary care centers recruited premature infants prospectively and retrospectively, and assigned affectation status based on the maximum degree of severity of ROP recorded in both eyes. Mutation screening of the FZD4 gene was(More)
OBJECTIVE The purpose of this study was to determine risk assessments for a spectrum of neonatal outcomes with elective cesarean delivery versus a trial of labor for previous cesarean section and otherwise healthy patients who deliver at term. STUDY DESIGN The perinatal/neonatal database of St. Joseph's Health Care, London, Ontario, Canada, was used to(More)
OBJECTIVE This cohort study investigated potential clinical and biochemical predictors of subsequent preterm birth in women presenting with threatened preterm labor. STUDY DESIGN AND SETTING Subjects were 218 pregnant women admitted to hospital with a diagnosis of threatened preterm labor at 22-36 weeks gestation. Exclusion criteria were multiple(More)
OBJECTIVE To evaluate the association between postpartum maternal depressive symptoms or maternal anxiety and health services utilization (HSU) for infants. DESIGN Telephone survey. SETTING London-Middlesex region of Ontario. PARTICIPANTS Mothers of infants 2 to 12 months of age between 2004 and 2005 (N = 655). This sample was drawn from a larger(More)
Although, in general, twins have higher perinatal mortality rates than singletons, preterm twins have lower perinatal mortality rates than singletons of the same birth weight or gestational age. This study investigated the hypotheses that this paradoxical twin advantage: 1) is due to gestational age distribution differences between the singleton and twin(More)
Labeling of goldfish optic nerve and tectum proteoglycans (PGs) was quantified following intraocular injection of 35SO4 and [3H]proline or [3H]glucosamine. Both intact animals and animals which had survived for periods of 10 to 119 days after an optic nerve crush lesion were examined. Regenerating retinal ganglion cell (RGC) axons reached the rostral pole(More)
OBJECTIVES To compare death and/or neurodevelopmental outcomes of preterm infants exposed to inhaled and/or systemic steroids with those without exposure, and examine the impact of timing of exposure. METHODS Retrospective study of infants born <29 weeks gestation and assessed at 18-21 months corrected age (CA). Neurodevelopmental impairment (NDI) was(More)
  • 1