Orlando Soto

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RATIONALE AND OBJECTIVES The authors' goal was to develop a noninvasive method for detailed assessment of blood flow patterns from direct in vivo measurements of vessel anatomy and flow rates. MATERIALS AND METHODS The authors developed a method to construct realistic patient-specific finite element models of blood flow in carotid arteries. Anatomic(More)
Atherosclerotic disease of the renal artery can lead to reduction in arterial caliber and ultimately to conditions including renovascular hypertension. Renal artery stenosis is conventionally assessed, using angiography, according to the severity of the stenosis. However, the severity of a stenosis is not a reliable indicator of functional significance, or(More)
Colloidal suspensions of iron oxide magnetic nanoparticles are known to dissipate energy when exposed to an oscillating magnetic field. Such energy dissipation can be employed to locally raise temperature inside a tumor between 41°C and 45°C (hyperthermia) to promote cell death, a treatment known as magnetic fluid hyperthermia (MFH). This work seeks to(More)
Magnetic fluid hyperthermia as a cancer treatment method is an attractive alternative to other forms of hyperthermia. It is based on the heat released by magnetic nanoparticles subjected to an alternating magnetic field. Recent studies have shown that magnetic fluid hyperthermia-treated cells respond significantly better to chemotherapeutic treatment(More)
This paper summarizes the major improvements and developments that have taken place during the last year for FEFLO, a general-purpose CFD code based on adaptive, unstructured grids. All aspects of a comprehensive CFD capability: gridding, solvers, mesh movement techniques, e ective use of supercomputer architectures and design saw important advances, and(More)
Computational fluid dynamics (CFD) models of the carotid artery are constructed from contrast-enhanced magnetic resonance angiography (MRA) using a deformable model and a surface-merging algorithm. Physiologic flow conditions are obtained from cine phase-contrast MRA at two slice locations below and above the carotid bifurcation. The methodology was tested(More)
Two design methodologies based on Incomplete-Gradient adjoint approaches for ow problems governed by the incompressible Navier-Stokes (NS) equations are presented. The main features of the algorithms is that they avoid solving the adjoint equations, saving an important amount of CPU time. Furthermore, the methodologies are general in the sense that they do(More)
The human evolutionary model is an intelligent global optimization method conceived to perform single and multiple objective optimization, this general method is still in development, especially the multi objective (MO) part is being improved. The single objective (SO) part has demonstrated that outperforms several algorithms that are in the state of the(More)