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  • Gülin Öz, Emily Kittelson, Döne Demirgöz, Orion Rainwater, H. Brent Clark
  • Medicine, Biology
  • Neurobiology of Disease
  • 2015 (First Published: 1 February 2015)
  • Suppression of transgene expression in a conditional transgenic mouse model of spinocerebellar ataxia 1 (SCA1) reverses the Purkinje cell pathology and motor dysfunction that are hallmarks of SCA1.Continue Reading
  • Jillian Friedrich, Holly B. Kordasiewicz, +17 authors Harry T. Orr
  • Biology, Medicine
  • JCI insight
  • 2018 (First Published: 2 November 2018)
  • Spinocerebellar ataxia type 1 (SCA1) is a dominantly inherited ataxia caused by expansion of a translated CAG repeat encoding a glutamine tract in the ataxin-1 (ATXN1) protein. Despite advances inContinue Reading
  • Aaron Mellesmoen, Carrie A Sheeler, Austin Ferro, Orion Rainwater, Marija Cvetanovic
  • Biology, Medicine
  • Front. Cell. Neurosci.
  • 2018 (First Published: 21 January 2019)
  • Spinocerebellar ataxia type 1 (SCA1) is a fatal neurodegenerative disease caused by an abnormal expansion of CAG repeats in the Ataxin-1 (ATXN1) gene and characterized by motor deficits andContinue Reading
  • Chao Jun Liu, Orion Rainwater, H. Brent Clark, Harry T. Orr, Taner Akkin
  • Biology, Medicine
  • Neurobiology of Disease
  • 2018 (First Published: 1 August 2018)
  • Spinocerebellar ataxia type 1 (SCA1) is a fatal inherited neurodegenerative disease. In this study, we demonstrate the label-free optical imaging methodology that can detect, with a high degree ofContinue Reading