Oriana Paoletti

Learn More
OBJECTIVE Over the last decade, the indications for oral anticoagulant therapy have been expanded considerably, resulting in a significant increase in the number of patients followed at an anticoagulation clinic (AC). Some organisational problems, in particular related to the healthcare staff and patients, have led to the need for decentralising the(More)
INTRODUCTION Systemic embolism is the most serious complication of cardioversion of atrial fibrillation (AF) and the immediate post-cardioversion period is associated with increased risk for thrombus formation. For this reason, treatment with vitamin K antagonist (VKA) is recommended for patients with AF. No information is available about bleeding risk(More)
Direct Oral AntiCoagulants (DOACs) were approved to reduce the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation (NVAF), for the prophylaxis of venous thromboembolism (VTE), in elective orthopaedic surgery, for treatment of acute VTE and prevention of recurrencies [1]. Apixaban is an orally active, direct selective factor(More)
INTRODUCTION Dabigatran etexilate is given in fixed doses without coagulation monitoring for the prevention of blood clots in at risk adults. A high inter-individual variability in blood concentrations of the active metabolite of dabigatran has been reported. ABCB1 and CES1 exert an important effect in the metabolism of dabigatran etexilate and allele(More)
INTRODUCTION Direct oral anticoagulant (DOAC) intra- and inter-individual variability was previously reported, but its magnitude is still considered negligible for patient management. OBJECTIVE To evaluate inter- and intra-individual variability in real-world atrial fibrillation patients on dabigatran, rivaroxaban or apixaban in four Italian(More)
Negli ultimi anni il numero dei pazienti trattati con farmaci anticoagulanti [eparine e antagonisti della vitamina K (AVK)] per la prevenzione e la cura del tromboembolismo venoso e per la prevenzione dell’ictus cardioembolico è cresciuto in modo esponenziale. A breve, quattro farmaci anticoagulanti orali ad azione diretta (DOA) inibente il fattore X(More)
Vitamin K antagonists (VKA) are the most widely used anticoagulants in the world. An appropriate management of treated patients is crucial for their efficacy and safety. The prospective, observational, multicenter, inception-cohort FCSA-START Register, a branch of START Register (NCT02219984) included VKA-treated patients managed by centers of Italian(More)
Cerebral vein thrombosis (CVT) is a rare disease usually affecting young people, especially women, with a high prevalence of thrombophilic defects. It is known that thrombophilia is associated with pregnancy complications; therefore, a high rate of complications could be expected in women with the previous CVT who become pregnant. This study examined the(More)