Orhan H Akman

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BACKGROUND Autosomal recessive mutations in MPV17 (OMIM *137960) have been identified in the hepatocerebral form of mitochondrial DNA depletion syndrome (MDS). OBJECTIVE To describe the clinical, morphologic, and genetic findings in 3 children with MPV17-related MDS from 2 unrelated families. DESIGN Case report. SETTING Academic research. MAIN(More)
The effects of cholesterol-loaded cyclodextrin (CLC) treatment on the osmotic tolerance and ability to undergo the acrosome reaction of rabbit spermatozoa, with an unusually high cholesterol/phospholipid ratio in plasma membranes, were examined in two successive experiments. In the first experiment, CLC-pretreated and untreated sperm cells were exposed for(More)
A 6-year-old boy had progressive muscle weakness since age 4 and emotional problems diagnosed as Asperger syndrome. His mother and two older siblings are in good health and there is no family history of neuromuscular disorders. Muscle biopsy showed ragged-red and cytochrome coxidase (COX)-negative fibers. Respiratory chain activities were reduced for all(More)
________________________________________________________________________________________ AKSU, E. H., F. M. KANDEMİR, K. KILIÇ, O. AKMAN, A. D. ÖMÜR, Ö. UÇAR: Arginase activity of ovarian structures in cows of Brown Swiss and its crossbreeds. Vet. arhiv 85, 261-271, 2015. ABSTRACT Arginase is the last enzyme of the urea cycle. It catalyses the hydrolysis of(More)
Results The incidence of AKI was 15.3% (n = 267) and of these RRT was performed on 69.6 % (n=185). The mortality rate among patients with AKI was 54 (20%) of 267 patients. Preoperative factors causing AKI revealed; angiotensin converting enzyme (ACE) inhibitors, prior recent acute myocardial infact (AMI) (< 6 weeks), euroscore. Postoperative factors causing(More)
Cortical spreading depression (CSD) is supposed to be the underlying biological basis of the migraine aura. Metoprolol was proven to be effective in migraine prophylaxis in clinical trials, but its mechanism of action has not been clarified yet. We studied direct effects of metoprolol on a continuous CSD induction model in rats. Six adult Wistar rats were(More)
Methods: After obtaining approval from the University Ethics Committee, This double-blind, randomized trial enrolled American Society of Anesthesiology (ASA) Class I III patients, aged 1 month to 12 years requiring MRI under deep sedation. One hundred and forty two patients were included in the study and were divided into 4 groups, prospectively.(More)
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