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Orexin/hypocretin role in reward: implications for opioid and other addictions
Addiction is a devastating disorder that affects 15.3 million people worldwide. While prevalent, few effective treatments exist. Orexin receptors have been proposed as a potential target forExpand
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Sifting through the surfeit of neuroinflammation tracers
The first phase of molecular brain imaging of microglial activation in neuroinflammatory conditions began some 20 years ago with the introduction of [11C]-(R)-PK11195, the prototype isoquinolineExpand
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Neuronal Nicotinic Acetylcholine Receptor Modulators Reduce Sugar Intake
Excess sugar consumption has been shown to contribute directly to weight gain, thus contributing to the growing worldwide obesity epidemic. Interestingly, increased sugar consumption has been shownExpand
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The effect of varenicline on binge-like ethanol consumption in mice is β4 nicotinic acetylcholine receptor-independent
BACKGROUND Our laboratory has previously shown that the smoking-cessation agent varenicline, an agonist/partial agonist of α4β2*, α3β4*, α3β2*, α6β2* (* indicates the possibility of additionalExpand
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5-HT1A receptor-dependent modulation of emotional and neurogenic deficits elicited by prolonged consumption of alcohol
Repeated episodes of binge-like alcohol consumption produce anxiety, depression and various deleterious effects including alterations in neurogenesis. While the involvement of the serotonin receptorExpand
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Binge-like sucrose consumption reduces the dendritic length and complexity of principal neurons in the adolescent rat basolateral amygdala
A compelling body of evidence suggests that the worldwide obesity epidemic is underpinned by excessive sugar consumption, typified by the modern western diet. Furthermore, evidence is beginning toExpand
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The antihypertensive drug pindolol attenuates long‐term but not short‐term binge‐like ethanol consumption in mice
Alcohol dependence is a debilitating disorder with current therapies displaying limited efficacy and/or compliance. Consequently, there is a critical need for improved pharmacotherapeutic strategiesExpand
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Modulation of serotonin and noradrenaline in the BLA by pindolol reduces long‐term ethanol intake
Repeated cycles of binge‐like alcohol consumption and abstinence change the activity of several neurotransmitter systems. Some of these changes are consolidated following prolonged alcohol use andExpand
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Serotonin and noradrenaline signalling in binge-like long-term alcohol intake and associated maladaptive effects in adult mice
Alcohol dependence is a debilitating disorder with current therapies displaying limited efficacy and/or compliance. This thesis investigated the contribution of two key neurotransmitters;Expand