We introduce a class of Multigrid based temporal difference algorithms for reinforcement learning with linear function approximation. Multigrid methods are commonly used to accelerate convergence of iterative numerical computation algorithms. The proposed Multigrid-enhanced TD(λ) algorithms allows to accelerate the convergence of the basic TD(λ) algorithm… (More)
Cells cope with replication-blocking lesions via translesion DNA synthesis (TLS). TLS is carried out by low-fidelity DNA polymerases that replicate across lesions, thereby preventing genome instability at the cost of increased point mutations. Here we perform a two-stage siRNA-based functional screen for mammalian TLS genes and identify 17 validated TLS… (More)
I am also indebt to Professor Irad Yavneh for his invaluable advice and support and for exposing me to field of Algebraic Multigrid.
CTLs act as the effector arm of the cell-mediated immune system to kill undesirable cells. Two processes regulate these effector cells to prevent self reactivity: a thymic selection process that eliminates autoreactive clones and a multistage activation or priming process that endows them with a license to kill cognate target cells. Hitherto no subsequent… (More)
Neural stem cells (NSCs) are progenitor cells for brain development, where cellular spatial composition (cytoarchitecture) and dynamics are hypothesized to be linked to critical NSC capabilities. However, understanding cytoarchitectural dynamics of this process has been limited by the difficulty to quantitatively image brain development in vivo. Here, we… (More)