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MOTIVATION Proteins underlay the functioning of a cell and the wiring of proteins in protein-protein interaction network (PIN) relates to their biological functions. Proteins with similar wiring in the PIN (topology around them) have been shown to have similar functions. This property has been successfully exploited for predicting protein functions.(More)
MOTIVATION Network comparison is a computationally intractable problem with important applications in systems biology and other domains. A key challenge is to properly quantify similarity between wiring patterns of two networks in an alignment-free fashion. Also, alignment-based methods exist that aim to identify an actual node mapping between networks and(More)
Exponential-family random graph models (ERGMs) are probabilistic network models that are parametrized by sufficient statistics based on structural (i.e., graph-theoretic) properties. The ergm package for the R statistical computing system is a collection of tools for the analysis of network data within an ERGM framework. Many different network properties(More)
We are flooded with large-scale dynamic networked data. Analyses requiring exact comparisons between networks are computationally intractable, so new methodologies are sought. We extend the graphlet-based statistics to directed networks and demonstrate that they are superior to other measures. We predict a country's gross domestic product (GDP) solely from(More)
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