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The high rate of brain metastasis in patients with advanced melanoma has been a clinical challenge for oncologists. Despite considerable progress made in the management of advanced melanoma over the past two decades, improvement in overall survival has been elusive. This is due to the high incidence of CNS metastases, which progress relentlessly and which(More)
In this paper we consider a homogeneous analytic center cutting plane method in a projective space. We describe a general scheme that uses a homogeneous oracle and computes an approximate analytic center at each iteration. This technique is applied to a convex feasibility problem, to variational inequalities, and to convex constrained minimization. We prove(More)
BACKGROUND Glycoprotein-96, a non-polymorphic heat-shock protein, associates with intracellular peptides. Autologous tumor-derived heat shock protein-peptide complex 96 (HSPPC-96) can elicit potent tumor-specific T cell responses and protective immunity in animal models. We sought to investigate the feasibility, safety, and antitumor activity of HSPPC-96(More)
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