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PepBind: A Comprehensive Database and Computational Tool for Analysis of Protein–peptide Interactions
Protein–peptide interactions, where one partner is a globular protein (domain) and the other is a flexible linear peptide, are key components of cellular processes predominantly in signaling and regulatory networks. Expand
Identification of novel tyrosine kinase inhibitors for drug resistant T315I mutant BCR-ABL: a virtual screening and molecular dynamics simulations study
BCR-ABL tyrosine kinase plays a major role in the pathogenesis of chronic myeloid leukemia (CML) and is a proven target for drug development. Currently available drugs in the market are effectiveExpand
Structural Epitope Database (SEDB): A Web-based Database for the Epitope, and its Intermolecular Interaction Along with the Tertiary Structure Information
An epitope is an antigenic determinant. It is a part of antigen, which is recognized by specific receptor of the immune system, exclusively by antibodies, B-cells or T-cells. Thus, exhaustiveExpand
Clostridium-DTDB: A comprehensive database for potential drug targets of Clostridium difficile
Clostridium difficile is considered to be one of the most important causes of health care-associated infections currently. Expand
Modeling, docking, simulation, and inhibitory activity of the benzimidazole analogue against β-tubulin protein from Brugia malayi for treating lymphatic filariasis
The nematode Wuchereria bancrofti and Brugia malayi are the causative agents of Lymphatic Filariasis, which is one of the leading causes of permanent and long-term disability in the world. TubulinExpand
Impact of rtI233V mutation in hepatitis B virus polymerase protein and adefovir efficacy: Homology modeling and molecular docking studies
Adefovir is an adenosine analogue approved by the Food and Drug Administration for the treatment of chronic hepatitis B. Mutations occurring in the hepatitis B virus (HBV) reverse transcriptase (rt)Expand
Essential proteins and possible therapeutic targets of Wolbachia endosymbiont and development of FiloBase-a comprehensive drug target database for Lymphatic filariasis
Lymphatic filariasis (Lf) is one of the oldest and most debilitating tropical diseases. Millions of people are suffering from this prevalent disease. It is estimated to infect over 120 million peopleExpand
Virological response and antiviral resistance mutations in chronic hepatitis B subjects experiencing entecavir therapy: an Indian subcontinent perspective.
Entecavir is one of the therapeutic options currently available for the management of chronic hepatitis B. In this study, we aimed to analyse the virological response and antiviral resistanceExpand
Drug targets for lymphatic filariasis: a bioinformatics approach.
This review article discusses the current scenario of the national and international burden due to lymphatic filariasis (LF) and describes the active elimination programmes for LF and theirExpand
Insight into the intermolecular recognition mechanism involved in complement component 4 activation through serine protease-trypsin
Serine protease cleaved-complement component 4 (C4) at sessile loop, which is significant for completion of lectin and classical complement pathways at the time of infections. The co-crystalizedExpand