Olof Vesterberg

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Amyotrophic lateral sclerosis (ALS) is a progressive and fatal degenerative disorder of motor neurons. The cause of this degeneration is unknown, and different causal hypotheses include genetic, viral, traumatic and environmental mechanisms. In this study, we have analyzed metal concentrations in cerebrospinal fluid (CSF) and blood plasma in a well-defined(More)
A method to study the protein binding patterns of trace elements in human cerebrospinal fluid (CSF) is described. Proteins in CSF samples were separated by size exclusion chromatography combined with high performance liquid chromatography (SEC-HPLC). The column was calibrated to separate proteins in the molecular weight range 6-70 kDa. Fractions were then(More)
Degenerative processes within the nervous system are common features in disease entities such as dementia of Alzheimer type (DAT), Parkinson disease (PD), and amyotrophic lateral sclerosis (ALS). ALS is a neurodegenerative disease with unknown etiology; widespread muscle wasting and respiratory failure lead to death within a few years. Denervation can be(More)
The limited resolution of serum proteins achieved with a simplified technique of two-dimensional electrophoresis (Clin. Chim. Acta 103: 51-59, 1980) has been improved by using different ampholyte (Ampholine) mixtures in the first dimension, to obtain relatively shallow pH gradients, and prolonged electrophoresis time in the second dimension. The technique(More)
Cadmium induced renal effects were examined in 60 workers (58 men, 2 women) previously exposed to cadmium. Tubular damage in the form of beta 2-microglobulinuria was found in 40%, and urinary albumin and orosomucoid increased significantly with increasing urinary cadmium and increasing relative clearance of beta 2-microglobulin. It is suggested that(More)
The lead concentration in CSF was determined by flameless atomic absorption spectrophotometry in 16 ALS patients and 22 control cases. The mean values were 0.69 +/- 0.55 (ALS) and 0.41 +/- 0.37 (controls), P < 0.01. This confirms our earlier findings of raised CSF lead levels in ALS but the present values are lower than previously reported for both ALS(More)
The lead content of cerebrospinal fluid (CSF) was found to be significantly elevated in 12 patients with amyotrophic lateral sclerosis, when compared to 28 control subjects having non-degenerative neurological disorders. The difference could not be explained as being merely secondary to blood-CSF barrier damage. A hypothetical model of the pathogenesis of(More)
The levels of lead in plasma were determined in 16 cases of amyotrophic lateral sclerosis (ALS) and 18 control subjects, using flameless atomic absorption spectrophotometry. The mean values were 0.52+/-0.22 microgram/100ml (ALS) and 0.37+/-0.13 microgram/100ml (controls), the difference is statistically significant (5% level). The values in both groups are(More)
BACKGROUND The prevalence of Alzheimer's disease is increasing. Could findings of similar deposits in brain and muscle tissue explain this increase? The purpose of this report is to illustrate that Alzheimer's disease and inclusion body myositis may share a common aetiology. RESULTS We present a case where Alzheimer's disease and inclusion body myositis(More)
The concentration of lead in the vastus lateralis muscle was determined in patients with amyotrophic lateral sclerosis and control subjects by flameless atomic absorption spectrophotometry. No statistically significant differences were found between these groups, and in both the figures were of the same magnitude as those earlier reported for normal(More)