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A unique Mycobacterium ESX‐1 protein co‐secretes with CFP‐10/ESAT‐6 and is necessary for inhibiting phagosome maturation
The ESX‐1 secretion system plays a critical role in the virulence of Mycobacterium tuberculosis and M. marinum. To date, three proteins are known to be secreted by ESX‐1 and necessary for virulence,… Expand
Allosteric signaling in the biotin repressor occurs via local folding coupled to global dampening of protein dynamics.
- Olli Laine, E. D. Streaker, Maryam Nabavi, C. Fenselau, D. Beckett
- Chemistry, Medicine
- Journal of molecular biology
- 1 August 2008
The biotin repressor is an allosterically regulated, site-specific DNA-binding protein. Binding of the small ligand bio-5'-AMP activates repressor dimerization, which is a prerequisite to DNA… Expand