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Regio- and stereospecific N-glucuronidation of medetomidine: the differences between UDP glucuronosyltransferase (UGT) 1A4 and UGT2B10 account for the complex kinetics of human liver microsomes.

• Sanna Kaivosaari, Päivi Toivonen, +4 authors Moshe Finel
• Drug metabolism and disposition: the biological…
• 2008

Medetomidine is a chiral imidazole derivate whose dextroenantiomer is pharmacologically active. The major metabolic pathway of dexmedetomidine [(+)-4-(S)-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole]… (More)

The N-glycome of human embryonic stem cells

• Tero Satomaa, Annamari Heiskanen, +13 authors Jarmo Laine
• BMC Cell Biology
• 2008

Complex carbohydrate structures, glycans, are essential components of glycoproteins, glycolipids, and proteoglycans. While individual glycan structures including the SSEA and Tra antigens are already… (More)

New Structural Variants of Aeruginosin Produced by the Toxic Bloom Forming Cyanobacterium Nodularia spumigena

• David P Fewer, Jouni Jokela, +7 authors Kaarina Sivonen
• PloS one
• 2013

Nodularia spumigena is a filamentous diazotrophic cyanobacterium that forms blooms in brackish water bodies. This cyanobacterium produces linear and cyclic peptide protease inhibitors which are… (More)

HA-detected experiments for the backbone assignment of intrinsically disordered proteins.

• Sampo Mäntylahti, Olli Aitio, Maarit Hellman, Perttu Permi
• Journal of biomolecular NMR
• 2010

We propose a new alpha proton detection based approach for the sequential assignment of natively unfolded proteins. The proposed protocol superimposes on following features: HA-detection (1) enables… (More)

Enterohaemorrhagic Escherichia coli exploits a tryptophan switch to hijack host f-actin assembly.

• Olli Aitio, Maarit Hellman, +4 authors Perttu Permi
• Structure
• 2012

Intrinsically disordered protein (IDP)-mediated interactions are often characterized by low affinity but high specificity. These traits are essential in signaling and regulation that require… (More)

Structural basis of PxxDY motif recognition in SH3 binding.

• Olli Aitio, Maarit Hellman, +6 authors Perttu Permi
• Journal of molecular biology
• 2008

We have determined the solution structure of epidermal growth factor receptor pathway substrate 8 (Eps8) L1 Src homology 3 (SH3) domain in complex with the PPVPNPDYEPIR peptide from the CD3epsilon… (More)

Recognition of tandem PxxP motifs as a unique Src homology 3-binding mode triggers pathogen-driven actin assembly.

• Olli Aitio, Maarit Hellman, +4 authors Perttu Permi
• Proceedings of the National Academy of Sciences…
• 2010

Src homology 3 (SH3) domains are globular protein interaction modules that regulate cell behavior. The classic SH3 ligand-binding site accommodates a hydrophobic PxxP motif and a positively charged… (More)

Glycomics of bone marrow-derived mesenchymal stem cells can be used to evaluate their cellular differentiation stage

• Annamari Heiskanen, Tia Hirvonen, +15 authors Leena Valmu
• Glycoconjugate Journal
• 2008

Human mesenchymal stem cells (MSCs) are adult multipotent progenitor cells. They hold an enormous therapeutic potential, but at the moment there is little information on the properties of MSCs,… (More)

The acceptor and site specificity of alpha 3-fucosyltransferase V. High reactivity of the proximal and low of the distal galbeta 1-4GlcNAc unit in i-type polylactosamines.

• M Pykäri, Sanna Toivonen, +11 authors Risto L O Renkonen
• The Journal of biological chemistry
• 2000

We report here on in vitro acceptor and site specificity of recombinant alpha3-fucosyltransferase V (Fuc-TV) with 40 oligosaccharide acceptors. Galbeta1-4GlcNAc (LN) and GalNAcbeta1-4GlcNAc (LDN)… (More)

Enzyme-assisted synthesis and structure characterization of glucuronic acid conjugates of losartan, candesartan, and zolarsartan.

• Anna Alonen, Johanna Jansson, +4 authors Risto Kostiainen
• Bioorganic chemistry
• 2008

Three angiotensin II receptor antagonists--losartan, candesartan, and zolarsartan--were investigated. All the compounds, which are structural analogues, are metabolized via conjugation to glucuronic… (More)

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