Olivier Tirel

Learn More
OBJECTIVE To evaluate the effect of a regular oropharyngeal application of povidone-iodine on the prevalence of ventilator-associated pneumonia in patients with severe head trauma. DESIGN Prospective randomized study. SETTING A surgical intensive care unit of a university hospital. INTERVENTIONS Patients with severe head trauma (Glasgow Coma Score of(More)
The aim of the present investigation was to apply a chemical delivery system (CDS) to MIBG (4) with the purpose of delivering this drug to the CNS. Compound 4 has been linked to a 1,4-dihydroquinoline moiety in order to achieve its CNS penetration, and here we report the synthesis to link 4 to the chemical delivery system and the radiosynthesis with(More)
BACKGROUND Endothelial dysfunction is common in patients with heart failure and is associated with poor clinical outcome. Cardiac rehabilitation is able to enhance peripheral endothelial function but its impact on coronary vasomotion remains unknown. We aimed to evaluate the effect of cardiac rehabilitation on coronary vasomotion in patients with heart(More)
Fludarabine has proven to be of considerable efficacy in the treatment of low-grade lymphomas. We have developed the labeling of this drug with fluorine-18 and evaluated 2-[18F]fludarabine as a novel positron emission tomography (PET) probe for in vivo imaging. Preclinical studies were conducted with 2-[18F]fludarabine, in parallel with(More)
An efficient and fully automated radiosynthesis of 2-[18F]fluoro-9-β-d-arabinofuranosyl-adenine (2-[18F]fludarabine, [18F]-5) based on a GE TRACERlab™ FX-FN module has been developed. A 2-nitro purine derivative 3 was developed as precursor for labeling with fluorine-18. The radiosynthesis of [18F]-5 was performed in two steps in a single reactor with an(More)
In this study, novel specific PET radioligands containing the 4-(4-fluorobenzyl)piperidine moiety and selectively antagonistic for the NR2B subunit containing NMDA receptors were developed. Two antagonists, RGH-896 (1a) and 4-(4-fluorobenzyl)piperidinyl-1-methyl-2-benzimidazol-5-ol (2a), belonging to two different structural families, were radiolabeled by(More)
Recently it has been argued that the linear relation between the transverse energy and the apparent probability to emit a fragment proves that the total system is in thermal equilibrium. It is shown, for the specific reaction Xe+Sn at 50 A.MeV, that the same behavior is obtained in the context of Quantum Molecular Dynamical without invoking the idea of(More)
BACKGROUND Few data are available in the literature on risk factors for postoperative vomiting (POV) in children. OBJECTIVE The aim of the study was to establish independent risk factors for POV and to construct a pediatric specific risk score to predict POV in children. METHODS Characteristics of 2392 children operated under general anesthesia were(More)
OBJECTIVE To determine the optimal saline volume bladder instillation to measure intravesical pressure in critically ill newborns weighing less than 4.5 kg, and to establish a reference of intra-abdominal pressure value in this population. DESIGN Prospective monocentric study. SETTING Neonatal ICU and PICU. PATIENTS Newborns, premature or not,(More)
This paper introduces a new method for the selection of central singlesource events, based on classical multivariate techniques. The resulting discriminating variable is shown to be valid for different hypotheses on the nuclear source deexcitation mechanism. It enables the selection of events which are representative of the whole set of single-source(More)