Olivier Bedel

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Heterozygous mutation of IDH1 in cancers modifies IDH1 enzymatic activity, reprogramming metabolite flux and markedly elevating 2-hydroxyglutarate (2-HG). Here, we found that 2-HG depletion did not inhibit growth of several IDH1 mutant solid cancer types. To identify other metabolic therapeutic targets, we systematically profiled metabolites in endogenous(More)
Cancer-associated point mutations in isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) confer a neomorphic enzymatic activity: the reduction of α-ketoglutarate to d-2-hydroxyglutaric acid, which is proposed to act as an oncogenic metabolite by inducing hypermethylation of histones and DNA. Although selective inhibitors of mutant IDH1 and IDH2 have been(More)
Today, the thematic layer is still the prevailling structure in geomatics for handling geographical information. However, the layer model is rigid: it implies partitionning geographical data in predefined categories and using the same description schema for all elements of a layer. Recently, Logical Information Systems (LIS) introduced a new paradigm for(More)
Because of the expansion of geo-positioning tools and the democratization of geographical information, the amount of geo-localized data that is available around the world keeps increasing. So, the ability to efficiently retrieve informations in function of their geographical facet is an important issue. In addition to individual properties such as position(More)
Geographical data are mainly structured in layers of information. However, this model of organisation is not convenient for navigation inside a dataset, and so limits geographical data exploration to querying. We think information retrieval could be made easier in GIS by the introduction of a navigation based on geographical object properties. For this(More)
We report on recent developments connecting FCA with other research areas, focussing on such with connections to Dresden. These include approaches to Rough Sets, to Dependencies, to Machine Learning, to Description Logics, and to Algebraic Biology. It seems that the systematic theoretical foundation of FCA paves the way to many different fields and that FCA(More)
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