Olivier Amedee-Manesme

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Studies on the incomplete fat absorption in newborns, particularly preterm ones, are reviewed. In the first week term breastfed newborns have a fat absorption coefficient of 91%. Lyophilization or pasteurigation reduces this figure in term as well as in preterm newborns. Excess Ca++ lowers fat absorption. So far, there is no evidence of immaturity of(More)
The possibility of malabsorption of triglycerides contained in the diets of children with cholestasis suggests a deficiency of essential fatty acids and, therefore, probable effects on eicosanoid metabolism. Children with either biliary atresia (BA) or syndromatic paucity of interlobular bile ducts (PILBD) were evaluated as to plasma and platelet total(More)
The vitamin A status in 11 generally healthy surgical patients was estimated by measuring the dilution of a 45-mg oral dose of tetradeuterated retinyl acetate (99% pure). After purification of retinol by high-performance liquid chromatography, the ratio of 2H4-retinol:1H-retinol in plasma was measured by gas chromatography-mass spectrometry. On the basis of(More)
Serum antioxidant vitamins A (retinol) and E (alpha-tocopherol), beta-carotene, zinc, and selenium, and cholesterol and related proteins for 170 children with newly diagnosed malignancy were measured at diagnosis and 6 months after initiation of treatment, and compared with those of 632 cancer-free controls. Incident cancer cases and controls were 1-16(More)
OBJECTIVES To determine whether beta carotene is therapeutically equivalent to retinyl palmitate in the formulation currently recommended by the World Health Organisation. DESIGN Randomised blind equivalence trial. SETTING Rural area in Senegal. SUBJECTS Children aged 2-15 years suffering from vitamin A deficiency as defined by abnormal results on eye(More)
The vitamin A status of 454 pre-school age Congolese children was evaluated by the impression cytology method with transfer (ICT) and by the determination of plasma retinol. The absence of goblet cells and the presence of enlarged epithelial cells indicate a peripheral deficit of vitamin A. A level of plasma retinol lower than 10 micrograms/dl is an(More)
The vitamin A status of 16 children with normal eyes and liver disease was evaluated by plasma retinol concentration and by liver vitamin A concentration or iv relative-dose-response test. Conjunctival impression cytology was performed on each child. All children with normal vitamin A status had normal conjunctival impression cytology. All children with(More)
A new case of neonatal glutaric aciduria type II is reported. Neonatal acidosis, hypoglycemia, and hyperammonemia were characteristic. The baby died at four days of age. Organic acid analysis revealed massive glutaric aciduria with elevated concentrations of butyric, isobutyric, n-butyric, and isovaleric acid in his urine. The baby's pedigree suggested(More)
Age- and sex-specific reference intervals of data derived from a healthy paediatric population are presented for retinol, beta-carotene, alpha-tocopherol, cholesterol and related proteins in serum. Age was an important covariate for the micronutrient concentration values. Retinol was highly correlated with alpha-tocopherol and cholesterol. Strong(More)