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In the mammalian retina, excess glutamate release has been shown to be involved in retinal ganglion cell (RGC) death associated with various diseases. Recent studies have determined that activation of alpha7 nicotinic acetylcholine receptors (nAChRs) partially protect isolated RGCs from glutamate-induced excitotoxicity. In this study, we further classify(More)
The presence and conservation of GnRH2 across vertebrate species suggest important biological roles. However, the function of GnRH2 remains unclear. A good research model for GnRH2 functional studies is still lacking largely due to the absence of GnRH2 in the widely used mouse model. Hence, we used the zebrafish, for which powerful genetic tools are(More)
The expression of soluble recombinant transglutaminase (TGase) has proven to be a challenge for many research groups. Herein, we report a complementary method for the expression, in BL21(DE3) Escherichia coli, of recombinant human tissue transglutaminase (hTG2) whose solubility is enhanced through N-terminal fusion to glutathione S-transferase (GST).(More)
This paper tackles a generalization of the weight constrained shortest path problem in a directed network (WCSPP) in which replenishment arcs, that reset the accumulated weight along the path to zero, appear in the network. Such situations arise, for example, in airline crew pairing applications, where the weight represents duty hours, and replenishment(More)
Tendon injuries occur commonly in horses and their repair through scar tissue formation predisposes horses to a high rate of re-injury. Pluripotent stem cells may provide a cell replacement therapy to improve tendon tissue regeneration and lower the frequency of re-injury. We have previously demonstrated that equine embryonic stem cells (ESCs) differentiate(More)
This year, AAAI's Conference on Artificial Intelligence honors the following papers that exemplify high standards in technical contribution and exposition. Candidate papers for the AAAI-13 awards were selected based on overall ratings and nominations by the PC and Senior PC. A committee composed of the Program Cochairs and several Associate Chairs and(More)
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