Olivera Sarenac

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To investigate the contribution of central vasopressin receptors to blood pressure (BP) and heart rate (HR) response to stress we injected non-peptide selective V(1a) (SR49059), V(1b) (SSR149415), V(2) (SR121463) receptor antagonists, diazepam or vehicle in the lateral cerebral ventricle of conscious freely moving rats stressed by blowing air on their heads(More)
This study investigates blood pressure (BP) and heart rate (HR) short-term variability and spontaneous baroreflex functioning in adult borderline hypertensive rats and normotensive control animals kept on normal-salt diet. Arterial pulse pressure was recorded by radio telemetry. Systolic BP, diastolic BP and HR variabilities and baroreflex were assessed by(More)
This study proposes a method for obtaining a stable working point that enables the unbiased estimates of the approximate entropy and the sample entropy. Pattern length, normalized threshold, time delay and tines series length are levels of freedom that are considered. Pulse interval signals used for the experiment are recorded from laboratory animals with(More)
receptors in the hypothalamic PVN increases baroreceptor reflex sensitivity and buffers BP variability in conscious rats. British Journal of Pharmacology, which has been published in final form at General rights This document is made available in accordance with publisher policies. Please cite only the published version using the reference above. Full terms(More)
The complexity quantification of physiologic signals is a field of considerable importance since loss of complexity has been proposed as a generic feature of pathological systems. This paper investigates entropy of the preprocessed time series of different laboratory animals -normal and borderline hypertensive rats. The systolic blood pressure and heart(More)
BACKGROUND AND PURPOSE The paraventricular nucleus (PVN) of the hypothalamus is an important integrative site for neuroendocrine control of the circulation. We investigated the role of oxytocin receptors (OT receptors) in PVN in cardiovascular homeostasis. EXPERIMENTAL APPROACH Experiments were performed in conscious male Wistar rats equipped with a(More)
Radiotelemetred male Wistar conscious rats were exposed to acute and chronic shaker stress and the spontaneous baroreceptor reflex (sBRR) functioning was evaluated using the method of sequences. Baroreflex sensitivity (BRS) is calculated using traditional, local and global approach. Contour coverage area (CCA, area embedding the sequence points in SBP-PI(More)
Heart rate and blood pressure short-term variability analysis represent promising quantitative measures of the cardiovascular autonomic controls. The analysis includes traditional statistical analytical tools and a number of methods based on nonlinear system theory, recently developed to give better insight into complex HR and BP time series. These methods(More)
This paper evaluates an exact formula for the number of the systolic blood pressure and pulse interval ramps, as well as spontaneous baroreflex sequences within the surrogate and artificial time series. It discusses the temporal sBR parameters of original and artificially generated data. 1. Introduction The baroreceptor reflex (BRR) is a major negative(More)
The hypothalamic paraventricular nucleus (PVN) is a key integrative site for the neuroendocrine control of the circulation and of the stress response. It is also a major source of the neuropeptide hormone vasopressin (VP), and co-expresses V1a receptors (V1aR). We thus sought to investigate the role of V1aR in PVN in cardiovascular control in response to(More)
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