Olivera Sarenac

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BACKGROUND AND PURPOSE It is well recognized that vasopressin modulates the neurogenic control of the circulation. Here, we report the central mechanisms by which vasopressin modulates cardiovascular response to stress induced by immobilization. EXPERIMENTAL APPROACH Experiments were performed in conscious male Wistar rats equipped with radiotelemetric(More)
To investigate the contribution of central vasopressin receptors to blood pressure (BP) and heart rate (HR) response to stress we injected non-peptide selective V(1a) (SR49059), V(1b) (SSR149415), V(2) (SR121463) receptor antagonists, diazepam or vehicle in the lateral cerebral ventricle of conscious freely moving rats stressed by blowing air on their heads(More)
The effect of emotional stress on the spontaneous baroreceptor reflex (sBRR) in freely moving rats was investigated. Six male Wistar rats equipped with an intra-arterial polyethylene catheter were exposed to a 2-min air-jet stress. For time course analysis of the sBRR response to stress, the records of systolic blood pressure (SBP) and pulse interval (PI)(More)
BACKGROUND AND PURPOSE The paraventricular nucleus (PVN) of the hypothalamus is an important integrative site for neuroendocrine control of the circulation. We investigated the role of oxytocin receptors (OT receptors) in PVN in cardiovascular homeostasis. EXPERIMENTAL APPROACH Experiments were performed in conscious male Wistar rats equipped with a(More)
This study proposes a method for obtaining a stable working point that enables the unbiased estimates of the approximate entropy and the sample entropy. Pattern length, normalized threshold, time delay and tines series length are levels of freedom that are considered. Pulse interval signals used for the experiment are recorded from laboratory animals with(More)
This study investigates blood pressure (BP) and heart rate (HR) short-term variability and spontaneous baroreflex functioning in adult borderline hypertensive rats and normotensive control animals kept on normal-salt diet. Arterial pulse pressure was recorded by radio telemetry. Systolic BP, diastolic BP and HR variabilities and baroreflex were assessed by(More)
This study investigates the contribution of central vasopressin receptors in the modulation of systolic arterial pressure (SAP) and heart rate (HR) response to air-jet stress in conscious Wistar rats equipped with a femoral arterial catheter and intracerebroventricular cannula using novel non-peptide and selective vasopressin V(1a) (SR49059) and V(1b)(More)
Radiotelemetred male Wistar outbrad rats and Borderline Hypertensive rats (BHR) were exposed to acute and chronic environmental stress. Approximate entropy (ApEn) approach is applied in order to investigate the pulse interval (PI) response to two different types of environmental stress: shaker and restrain stress. The performance of ApEn method was(More)
The complexity quantification of physiologic signals is a field of considerable importance since loss of complexity has been proposed as a generic feature of pathological systems. This paper investigates entropy of the preprocessed time series of different laboratory animals -normal and borderline hypertensive rats. The systolic blood pressure and heart(More)
The hypothalamic paraventricular nucleus (PVN) is a key integrative site for the neuroendocrine control of the circulation and of the stress response. It is also a major source of the neuropeptide hormone vasopressin (VP), and co-expresses V1a receptors (V1aR). We thus sought to investigate the role of V1aR in PVN in cardiovascular control in response to(More)