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OBJECTIVES Several studies indicate that high-volume hospitals have better results in open repair of unruptured abdominal aortic aneurysms (AAA). Up to now no studies had addressed this question in German hospitals. DESIGN Post-hoc-analysis from a prospective physician-led registry. MATERIAL AND METHODS Since 1999, the German Society for Vascular(More)
The cerebral deposition of amyloid beta-peptide, a central event in Alzheimer's disease (AD) pathogenesis, begins several years before the onset of clinical symptoms. Noninvasive detection of AD pathology at this initial stage would facilitate intervention and enhance treatment success. In this study, high-field MRI was used to detect changes in regional(More)
Nach Abschluss mehrerer prospektiv-randomisierter Multicenterstudien (ECST, NASCET, ACAS, ACST) stellt die operative Desobliteration extrakranieller Karotisstenosen eine im Sinne der evidenzbasierten Medizin (EBM) bewiesene Maßnahme in der Prophylaxe des karotisbedingten Schlaganfalls dar. Sicherheit und Wirksamkeit der stentgestützten Karotisangioplastie(More)
BACKGROUND AND PURPOSE Embolic events are a major cause for procedure-related strokes after carotid endarterectomy (CEA). Transcranial Doppler sonography can reveal embolic events as microembolic signals (MES) during CEA. MES during declamping and shunting are frequently detected. MES during shunting are rare and known to be correlated with the neurological(More)
BACKGROUND AND PURPOSE The present study investigated the prevalence of cerebral microemboli detected by transcranial Doppler sonography in unselected stroke and transient ischemic attack (TIA) patients under standard clinical conditions. We aimed to evaluate the feasibility and the value of the method for clinical use. METHODS The records of 937(More)
The benefit of carotid endarterectomy in symptomatic high-grade stenosis has long been proven. The role of angioplasty as an alternative is still a matter of debate. We compared the occurrence of intraprocedural microembolic signals and ischemic lesions between carotid endarterectomy (CEA) and carotid angioplasty with stent placement (CAS) without a(More)
Transforming growth factor beta (TGF-beta) has multiple effects on bone cell metabolism in vitro but its exact role in bone remodeling still needs to be defined. Here we demonstrate that TGF-beta is chemotactic for osteoblastlike cells from fetal rat calvariae and osteoblastlike ROS 17/2.8 osteosarcoma cells. Maximal chemotaxis occurred at 5-15 pg/ml of(More)
Carotid artery stenosis can be classified by magnetic resonance imaging (MRI) as lesion types I–VIII according to a modified histological scheme based on American Heart Association (AHA) guidelines. Lesion types IV–V and VI are regarded as high-risk plaques.We aimed to evaluate the clinical relevance of this classification for identifying unstable plaques.(More)
To study the influence of a newly developed membrane stent design on flow patterns in a physiologic carotid artery model. Three different stents were positioned in silicone models of the carotid artery: a stainless steel stent (Wall-stent), a nitinol stent (SelfX), and a nitinol stent with a semipermeable membrane (MembraX). To increase the contact area of(More)
The purpose of the present study was to assess the course of adhesion molecules (intercellular adhesion molecule (ICAM), vascular cell adhesion molecule (VCAM), e-selectin, p-selectin and monocyte chemoatlractant protein 1 (MCP-1)), growth factors (transforming growth factor beta (TGFbeta) and basic fibroblast growth factor (bFGF)) and the cytokine tumour(More)