Oliver Turschner

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BACKGROUND Enzyme replacement therapy (ERT) has been shown to enhance microvascular endothelial globotriaosylceramide clearance in the hearts of patients with Fabry disease. Whether these results can be translated into an improvement of myocardial function has yet to be demonstrated. METHODS AND RESULTS Sixteen patients with Fabry disease who were treated(More)
UNLABELLED Intracardiac Echocardiography Guided Cryoballoon Ablation. BACKGROUND Cryoballoon ablation is increasingly used for pulmonary vein isolation (PVI) in patients with atrial fibrillation (AF). This new technique aims to perform PVI safer and faster. However, procedure and fluoroscopy times were similar to conventional RF approaches. We compared(More)
OBJECTIVE The long-term effects and mechanisms of early started angiotensin converting enzyme (ACE) inhibition post myocardial infarction (MI) are not well understood. Chronic effects of early ACE inhibition on hemodynamics, left ventricular diastolic wall stress and remodeling were, therefore, compared to that of angiotensin AT1-receptor subtype blockade(More)
Since the implementation of cardiac resynchronization therapy (CRT) the prognosis of patients with severe heart failure has been improved owing to a reduction in morbidity and mortality rates, as several multicenter trials have shown. However, several patients treated by CRT still lack improvement or even deteriorate during therapy. In some of them, this(More)
OBJECTIVES The Troponin in Planned PTCA/Stent Implantation With or Without Administration of the Glycoprotein IIb/IIIa Receptor Antagonist Tirofiban (TOPSTAR) trial investigated: 1) the amount of troponin T (TnT) release after nonacute, elective percutaneous coronary intervention (PCI) in patients pretreated with aspirin and clopidogrel; and 2) the effect(More)
AIM Successful primary PTCA (with TIMI 3 reflow) in patients with acute transmural infarction has been observed to result in an immediate abnormal increase in wall thickness associated with persisting abnormal post-systolic thickening. To understand the sequential changes in regional deformation during: (i) the development of acute transmural infarction,(More)
Background Cardiac MRI (cMRI) has become an effective and feasible tool to identify the anatomy of the left atrium and the pulmonary veins (PV) prior to pulmonary vein ablation (PVI) in patients with atrial fibrillation (AF). It is still difficult to predict the potential success of a PVI. Methods 254 patients (176 male, 62.3±10.5 years) with AF were(More)
We investigated the in vitro fibrinolytic properties of microplasmin, the isolated proteinase domain of plasmin, and its thrombolytic efficacy in a coronary artery thrombosis model in dogs. The amidolytic and fibrinolytic activity of recombinant microplasmin was compared with natural human plasmin. The thrombolytic efficacy of microplasmin was studied in a(More)
AIMS To compare ablation lesion formation after pulmonary vein isolation (PVI) using the standard cryoballoon (CB-S) vs. the re-designed cryoballoon Arctic Front Advance (CB-A) using late gadolinium enhancement magnetic resonance imaging (LGE-MRI) 3 months post-ablation. METHODS AND RESULTS Thirty-six consecutive patients with paroxysmal or short-lasting(More)
Vorhofflimmern ist nach wie vor ein schwieriges therapeutisches Problem, das mit einer Verschlechterung der Herzinsuffizienzsymptome, einer erhöhten Schlaganfallquote und einer ansteigenden Mortalität verbunden ist. Neue Therapieansätze müssen nicht nur die Effektivität erhöhen, sondern auch das Sicherheitsprofil verbessern, um bei älteren Patienten mit(More)