Oliver Trapp

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To deal with different kinds of DNA damages, there are a number of repair pathways that must be carefully orchestrated to guarantee genomic stability. Many proteins that play a role in DNA repair are involved in multiple pathways and need to be tightly regulated to conduct the functions required for efficient repair of different DNA damage types, such as(More)
Since the initial discovery of genes involved in hereditary breast cancer in humans, a vast wealth of information has been published. Breast cancer proteins were shown to work as tumor suppressors primarily through their involvement in DNA-damage repair. Surprisingly, homologs of these genes can be found in plant genomes, as well. Here, we want to give an(More)
BACKGROUND The weaning target in tracheotomised patients is not extubation, but spontaneous breathing without the support of a ventilator. Overloading the respiratory pump during such spontaneous breathing trials is unfavorable, prolongs weaning time, and increases morbidity and mortality. The goal of this study was to evaluate the electrical activity of(More)
DNA polymerase zeta catalytic subunit REV3 is known to play an important role in the repair of DNA damage induced by cross-linking and methylating agents. Here, we demonstrate that in Arabidopsis (Arabidopsis thaliana), the basic polymerase activity of REV3 is essential for resistance protection against these different types of damaging agents.(More)
  • Philipp Herwig, Kerstin Zawatzky, Manfred Grieser, Oded Heber, Brandon Jordon-Thaden, Claude Krantz +8 others
  • 2013
In chemistry and biology, chirality, or handedness, refers to molecules that exist in two spatial configurations that are incongruent mirror images of one another. Almost all biologically active molecules are chiral, and the correct determination of their absolute configuration is essential for the understanding and the development of processes involving(More)
Conformational and configurational changes such as isomerizations, epimerizations, diastereomerizations and, enantiomerizations are important for the investigation of a large variety of processes ranging from protein folding to the stereostability of drugs. Under optimized conditions, these processes lead to an elution profile characterized by a plateau(More)
The software program ChromWin simulates interconversion profiles in dynamic chromatography (rearrangements, isomerizations, epimerizations, diastereomerizations and, notably, enanatiomerizations) on a personal computer in a user-friendly environment. ChromWin is especially suited for systems involving large plate numbers, e.g. gas chromatography (GC) and(More)
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