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Critical role for NF-kappaB-induced JunB in VEGF regulation and tumor angiogenesis.
TLDR
It is demonstrated that the AP-1 subunit junB is a target gene of hypoxia-induced signaling via NF-kappaB and identified JunB as a critical independent regulator of VEGF transcription and provides a mechanistic explanation for the inherent vascular phenotypes seen in JunB-deficient embryos, ex vivo allantois explants and in vitro differentiated embryoid bodies. Expand
Critical role for NF‐κB‐induced JunB in VEGF regulation and tumor angiogenesis
TLDR
It is demonstrated that the AP‐1 subunit junB is a target gene of hypoxia‐induced signaling via NF‐κB and identified JunB as a critical independent regulator of VEGF transcription and provides a mechanistic explanation for the inherent vascular phenotypes seen in JunB‐deficient embryos, ex vivo allantois explants and in vitro differentiated embryoid bodies. Expand
JunB is required for endothelial cell morphogenesis by regulating core-binding factor β
TLDR
It is demonstrated that cell-autonomous endothelial functions of the AP-1 subunit JunB are required for proper endothelial morphogenesis both in vivo in mouse embryos with endothelial-specific ablation of JunB and in in vitro angiogenesis models. Expand