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MOTIVATION New developments in post-genomic technology now provide researchers with the data necessary to study regulatory processes in a holistic fashion at multiple levels of biological organization. One of the major challenges for the biologist is to integrate and interpret these vast data resources to gain a greater understanding of the structure and(More)
In Saccharomyces cerevisiae, Cdc13 binds telomeric DNA to recruit telomerase and to "cap" chromosome ends. In temperature-sensitive cdc13-1 mutants telomeric DNA is degraded and cell-cycle progression is inhibited. To identify novel proteins and pathways that cap telomeres, or that respond to uncapped telomeres, we combined cdc13-1 with the yeast gene(More)
Developing a complex software system involves decisions about how to allocate a limited resource budget among a collection of costly software alternatives (such as technologies or analysis techniques) that have uncertain future benefits. Very little quantitative guidance is currently available to make these decisions. We suggest that these allocation(More)
Stochastic simulations are able to capture the fine grain behaviour and randomness of outcome of biological networks not captured by deterministic techniques. As such they are becoming an increasingly important tool in the biological community. However, current efforts in the stochastic simulation of biological networks are hampered by two main problems:(More)
Systems Biology is a rapidly developing discipline which utilises mathematical and computer science techniques to analyse and interpret biological models. Petri nets have been proposed as an effective formalism for Systems Biology but so far only a small number of simple manual Petri net models have been constructed and investigated. In this paper we(More)
The Centre for Integrated Systems Biology of Ageing and Nutrition has developed a Data Portal and Integrator (CISBAN DPI) that is based on the FuGE Object Model and which archives, stores, and retrieves raw high-throughput data. Until now, few published systems have successfully integrated multiple omics data types and information about experiments in a(More)
The challenge of publishing internationally for non-native English speakers (NNESs) is substantial, although there are conflicting accounts as to how NNES-authored texts fare in English-medium journals and the nature of the criticism levied at these texts. Collaborators from a wide variety of backgrounds and skill sets may contribute to these texts, and the(More)
AIMS Lack of consensus in HLA antibody reporting in proficiency schemes has previously been attributed to a number of differing factors. This study was set up to eliminate the majority of these factors by reducing analysis to a pure data handling exercise. METHODS Anonymised raw data files for LABScreen Single Antigen class I and II and related patient(More)
The incidence of ductal carcinoma in situ (DCIS) is increasing with the use of screening mammography, and approximately 30% of all women diagnosed with DCIS are treated by mastectomy. There is increasing use of a skin-sparing mastectomy (SSM) approach to surgically excise DCIS as this facilitates immediate breast reconstruction. The rates of locoregional(More)