• Publications
  • Influence
A Phenotypic Profile of the Candida albicans Regulatory Network
Candida albicans is a normal resident of the gastrointestinal tract and also the most prevalent fungal pathogen of humans. It last shared a common ancestor with the model yeast SaccharomycesExpand
  • 339
  • 49
  • PDF
Biofilm Matrix Regulation by Candida albicans Zap1
The zinc-responsive transcription factor Zap1 has a striking role in fungal biofilm formation and is reported to regulate matrix formation.
  • 259
  • 22
  • PDF
MochiView: versatile software for genome browsing and DNA motif analysis
BackgroundAs high-throughput technologies rapidly generate genome-scale data, it becomes increasingly important to visually integrate these data so that specific hypotheses can be formulated andExpand
  • 127
  • 14
  • PDF
Dominant gain-of-function mutations in Hsp104p reveal crucial roles for the middle region.
Heat-shock protein 104 (Hsp104p) is a protein-remodeling factor that promotes survival after extreme stress by disassembling aggregated proteins and can either promote or prevent the propagation ofExpand
  • 106
  • 13
  • PDF
A Conserved Transcriptional Regulator Governs Fungal Morphology in Widely Diverged Species
Fungi exhibit a large variety of morphological forms. Here, we examine the functions of a deeply conserved regulator of morphology in three fungal species: Saccharomyces cerevisiae, Candida albicans,Expand
  • 62
  • 7
  • PDF
Harnessing Natural Diversity to Probe Metabolic Pathways
Analyses of cellular processes in the yeast Saccharomyces cerevisiae rely primarily upon a small number of highly domesticated laboratory strains, leaving the extensive natural genetic diversity ofExpand
  • 63
  • 5
  • PDF
Whole-genome sequencing in multiplex families with psychoses reveals mutations in the SHANK2 and SMARCA1 genes segregating with illness
A current focus in psychiatric genetics is detection of multiple common risk alleles through very large genome-wide association study analyses. Yet families do exist, albeit rare, that have multipleExpand
  • 54
  • 3
Drug Repurposing: The Anthelmintics Niclosamide and Nitazoxanide Are Potent TMEM16A Antagonists That Fully Bronchodilate Airways
There is an unmet need in severe asthma where approximately 40% of patients exhibit poor β-agonist responsiveness, suffer daily symptoms and show frequent exacerbations. Antagonists of theExpand
  • 33
Drug Repurposing: The Anthelmintics Niclosamide and Nitazoxanide are Potent TMEM16A Antagonists that Fully Bronchodilate Airways
There is an unmet need in severe asthma where approximately 40% of patients exhibit poor β-agonist responsiveness, suffer daily symptoms and show frequent exacerbations. Antagonists of theExpand
  • 2
...
1
2
...