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ardy–Weinberg equilibrium (HWE) is the state of the genotypic frequency of two alleles of one autosomal gene locus after one discrete generation of random mating in an indefinitely large population: if the alleles are A and a with frequencies p and q (=1-p), then the equilibrium gene frequencies are simply p and q and the equilibrium genotypic frequencies(More)
Because directional selection exhausts additive-genetic variance, it is frequently claimed that the heritability of fitness should be very close to zero. However, mutation-selection balance generates a certain amount of additive-genetic variance, so that even parent-offspring measures of heritability may be greater than zero at equilibrium. Intra-generation(More)
The approach to linkage equilibrium of a locus linked to the locus determining gametophytic self-incompatibility (S) is considered. For the simplest case of three alleles at the S locus and two at the linked locus it is necessary to consider 3 measures of linkage disequilibrium. These are found to approach their equilibrium value of zero in one of three(More)
Major genes affecting quantitative traits are widespread and well known. However, major genes affecting unimodally distributed quantitative traits appear to be rare in populations of outbreeding organisms. This may largely reflect methods of analysis, or it may reflect the interaction of chance and selection on the frequencies of such major genes. If many(More)
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