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Associations between polymorphisms and disease are usually detected by comparing phenotype frequencies in affected individuals and controls, usually by the method of Woolf, which also allows assessment of heterogeneity between studies. The risk of reporting a chance spurious association could be reduced if family studies, such as sib comparisons, were(More)
  • Oliver Mayo
  • 2008
Hardy-Weinberg equilibrium (HWE) is the state of the genotypic frequency of two alleles of one autosomal gene locus after one discrete generation of random mating in an indefinitely large population: if the alleles are A and a with frequencies p and q(=1-p), then the equilibrium gene frequencies are simply p and q and the equilibrium genotypic frequencies(More)
Data on family size distribution and inheritance are presented. Variance in sibship size is in general greater than mean sibship size. The inherited component in the variation appears in general to be small, though not in a Scottish sample examined in more detail. Changes in family size distribution for social (or other) reasons are considered, together(More)
The concept of genetical load is placed in the historical context, and distinguished from a related concept, the cost of natural selection. Different types of load are examined theoretically, in the light of their relevance to Man, and the importance of diversity is emphasized. The extent of the load and its changing nature are discussed, with particular(More)