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The chemokine receptor CCR5 is predominantly expressed on monocytes and Th1-polarized T cells, and plays an important role in T cell and monocyte recruitment in inflammatory diseases. To investigate the functional role of CCR5 in renal inflammation, we induced a T cell-dependent model of glomerulonephritis (nephrotoxic serum nephritis) in CCR5(-/-) mice.(More)
The recruitment of inflammatory cells into renal tissue, mainly T cells and monocytes, is a typical feature of various renal diseases such as glomerulonephritis, thrombotic angiopathies, allograft rejection, and vasculitis. T cells predominantly infiltrate the tubulointerstitium, whereas monocytes are present in the tubulointerstitial and glomerular(More)
The cytokine IL-6 plays a protective role in immune responses against bacterial infections. However, the mechanisms of IL-6-mediated protection are only partially understood. IL-6 can signal via the IL-6R complex composed of membrane-bound IL-6Rα (mIL-6Rα) and gp130. Owing to the restricted expression of mIL-6Rα, classical IL-6 signaling occurs only in a(More)
Micromanipulation is an appreciated and powerful method to modify biological material. By injecting DNA or specific liquids into a biological cell, designated reactions or behaviors can be provoked. The aim of this paper is to describe three components of a fully automated opticonsisting of a micro-robot cluster with an integrated micro-fluidic SyringeChip.(More)
BJ: The cost-effectiveness of maintaining higher hemoglobin targets with erythropoietin in hemodialysis patients. M: Venous thromboembolism and mortality associated with recombinant erythropoietin and darbepoetin administration for the treatment of cancer-associated anemia. Our choice of partners, so they say, is subconsciously directed by an immune system(More)
Multiple studies have identified CD4+ T cells as central players of glomerulonephritis (GN). Cells of the Th1 and Th17 responses cause renal tissue damage, while Tregs mediate protection. Recently, a high degree of plasticity among these T cell lineages was proposed. During inflammation, Th17 cells were shown to have the potential of transdifferentiation(More)
A specific integrated controller for a wireless and autonomous microrobot of 1 cm<sup>3</sup> is presented. The microrobot is equipped with an atomic force microscopy (AFM) probe, a syringe or a gripper to develop cooperative tasks in biological experiences. Its main functionality and the controller design is focused on nanomicroscopy and cellular(More)
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