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  • Marilia A. Calcia, David R Bonsall, Peter S Bloomfield, Sudhakar Selvaraj, Tatiana Barichello, Oliver D. Howes
  • Psychology, Medicine
  • Psychopharmacology
  • 2016 (First Publication: 5 February 2016)
  • RationalePsychosocial stressors are a well-documented risk factor for mental illness. Neuroinflammation, in particular elevated microglial activity, has been proposed to mediate this association. AContinue Reading
  • Michael A. P. Bloomfield, Celia J A Morgan, Alice Egerton, Shitij Kapur, Oliver D. Howes
  • Psychology, Medicine
  • Biological Psychiatry
  • 2014 (First Publication: 1 March 2014)
  • BACKGROUND Cannabis is the most widely used illicit drug globally, and users are at increased risk of mental illnesses including psychotic disorders such as schizophrenia. Substance dependence andContinue Reading
  • Jonathan P. Roiser, Oliver D. Howes, Christopher A. Chaddock, Eileen M. Joyce, Philip Mcguire
  • Psychology, Medicine
  • Schizophrenia bulletin
  • 2013 (First Publication: 12 December 2012)
  • The “aberrant salience” model proposes that psychotic symptoms first emerge when chaotic brain dopamine transmission leads to the attribution of significance to stimuli that would normally beContinue Reading
  • Alice Egerton, Arsime Demjaha, Philip K. McGuire, Mitul A. Mehta, Oliver D. Howes
  • Psychology, Medicine, Computer Science
  • NeuroImage
  • 2010 (First Publication: 1 April 2010)
  • Brain presynaptic dopaminergic function can be assessed using 18F-DOPA positron emission tomography (PET). Regional 18F-DOPA utilization may be used to index dopaminergic abnormalities over time orContinue Reading