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Hemolytic uremic syndrome (HUS) is characterized by hemolytic anemia with fragmented erythrocytes, thrombocytopenia, and acute renal failure. Lack of complement inactivating factor H predisposes to the development of atypical HUS. Little is known about mechanisms linking complement activation with loss of erythrocyte integrity during HUS. Recent studies(More)
Atypical hemolytic uremic syndrome (aHUS) in childhood is a rare disease associated with high morbidity and mortality. Most cases progress to end-stage renal failure. In approximately 50% of affected patients, mutations in genes encoding complement proteins are causative of the impairment in the regulation of the complement alternative pathway. This leads(More)
Standard therapy for lupus nephritis is based on non-specific immunosuppression. We aimed to identify specific alterations in T cell and cytokine homeostasis and possible associations with disease activity in children with lupus nephritis (LN). The phenotype of circulating T cells from children with LN and healthy controls (HC) was analyzed by flow(More)
Current treatment regimens for childhood lupus nephritis (LN) are associated with significant side-effects and toxicity in vulnerable phases of growth and development. The paucity of biomarkers particularly in childhood impedes the appropriate clinical management and the development of new therapeutics. We analyzed markers of immune system (BAFF, RANTES),(More)
Bei Pilzvergiftungen kurzer Latenz werden Vergiftungen mit vorwiegend gastrointestinaler Wirkung und rein symptomatischer Therapie von Vergiftungen mit zentralnervöser Wirkung unterschieden. Letztere werden in Muskarin- (Durchfall, Erbrechen, cholinerge Symptome — Therapie: Flüssigkeits- und Elektrolytausgleich, Gabe des spezifischen Antagonisten Atropin),(More)
OBJECTIVE To demonstrate a rare case of urological pathology, we report a combination of a single kidney and ureteral atresia. The treatment concept and outcome are outlined. PATIENT AND METHOD Antenatal ultrasound had revealed urinary ascites which lead to caesarean section in the 34th gestational week. Persisting anuria was confirmed postnatally and(More)
Fallbericht. Das Muckle-Wells-Syndrom ist eine autosomal-dominant vererbte Erkrankung, die durch die Trias Innenohrschwerhörigkeit, rezidivierend auftretendes urtikarielles Exanthem und – prognostisch am bedeutsamsten – eine systemische Amyloidose gekennzeichnet ist.Der zugrunde liegende Defekt konnte kürzlich identifiziert werden und befindet sich auf dem(More)
The release of hemoglobin from mechanically stressed erythrocytes into plasma is a general side effect of extracorporeal therapies, such as extracorporeal membrane oxygenation or hemodialysis. In many reported cases dialysis patients showed elevated cell-free plasma hemoglobin (CPH) levels which are associated with pathophysiological effects. In this in(More)
Surgical approach to children with complicated ureteral duplication is discussed controversially. Our aim was to determine the outcome of children with complicated renal duplication undergoing a single-stage surgical approach with laparoscopic partial nephrectomy and open bladder reconstruction. Data of patients from 2004 to 2008 were investigated(More)
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