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TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis
Although there has been much success in identifying genetic variants associated with common diseases using genome-wide association studies (GWAS), it has been difficult to demonstrate which variantsExpand
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Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity
Resolving TYK2 locus genotype-to-phenotype differences reveals an immune signaling optimum that may be exploited therapeutically for treating autoimmune diseases. TYK2’s balancing act Determining theExpand
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CD8+ MAIT cells infiltrate into the CNS and alterations in their blood frequencies correlate with IL‐18 serum levels in multiple sclerosis
Recent findings indicate a pathogenic involvement of IL‐17‐producing CD8+ T cells in multiple sclerosis (MS). IL‐17 production has been attributed to a subset of CD8+ T cells that belong to theExpand
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