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Of three human neuroblastoma lines tested, IMR32K (and IMR32 parental line) was the only cell line that, after its exposure to a differentiation medium, consistently developed materials recognized immunocytochemically by a panel of antibodies against paired helical filaments (PHF). Ultrastructurally, these cells accumulated, at their perikarya and neuritic(More)
Accumulation of paired helical filaments (PHF) in neurofibrillary tangles is a key neuropathological hallmark in Alzheimer's disease (AD). To date, PHF have been found primarily in humans. Cultured murine cholinergic neuroblastoma (S20Y) cells, following exposure to a serum-free medium or a differentiation medium, developed immunoreactivity to anti-PHF(More)
Report is made of the first two cases in which psammoma bodies were detected in peritoneal washings. The significance of psammoma bodies in a cytologic specimen is reviewed. These case reports and review of the literature make it clear that the cytologic detection of psammoma bodies should be a stimulus for further investigation but that the diagnosis of(More)
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