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Journals and Conferences
Serine proteases play critical roles in a variety of insect immune responses; however, few of the genes that code for these enzymes have been cloned. Here, we describe the molecular characterization… (More)
We identified five new serine protease cDNAs from the hemolymph of the malaria vector, Anopheles gambiae. All five show sequence similarity to genes thought to be involved in vertebrate or… (More)
A macrocyclic conjugate of the natural diterpenoid isosteviol (16-oxo-ent-beyeran-19-oic acid) and glucuronic acid was synthesized for the first time. The conjugate contained two molecules of… (More)
A derivative of the Stevia rebaudiana glycoside steviolbioside in which two molecules containing thiazolylhydrazone groups on C-16 atoms were connected through a polymethylene linker to their… (More)
Previously unknown conjugates of the diterpenoid isosteviol 1 and 1-O-methyl-2,3-di-O-acetyl-β-Darabinofuranoside in which the terpenoid and carbohydrate molecules were linked through polymethylene… (More)
Conjugates of the antituberculosis drug isoniazid (isonicotinyl hydrazine) and isomeric hydrazides of nicotinic and α-picolinic acid with glycoside steviolbioside from the Stevia rebaudiana plant and… (More)
Melanization is a mechanism of innate immunity in arthropods wherein a thick capsule of melanin is formed around foreign objects. Little is known about this pathway biochemically though serine… (More)
A macrocyclic glycoterpenoid containing the diterpenoid dihydroisosteviol (16-hydroxy-ent-beyeran-19- oic acid) and α,α′-trehalose linked by an ester spacer was synthesized.
The first macrocyclic glycoterpenoids comprising glucosamine and diterpenoid isosteviol moieties were synthesized and evaluated for inhibition activity against Mycobacterium tuberculosis H37Rv.
Conjugates of the diterpenoid isosteviol (16-oxo-ent-beyeran-19-oic acid) and glucuronic acid containing two diterpenoid (ent-beyerane) skeletons joined by a 1,6-hexanedicarboxylate spacer and… (More)