Olga Tsoulaki

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The Core Binding Factor (CBF) protein RUNX1 is a master regulator of definitive hematopoiesis, crucial for hematopoietic stem cell (HSC) emergence during ontogeny. RUNX1 also plays vital roles in adult mice, in regulating the correct specification of numerous blood lineages. Akin to the other mammalian Runx genes, Runx1 has two promoters P1 (distal) and P2(More)
Acute myeloid leukaemia (AML) is characterized by a block in myeloid differentiation the stage of which is dependent on the nature of the transforming oncogene and the developmental stage of the oncogenic hit. This is also true for the t(8;21) translocation that gives rise to the RUNX1-ETO fusion protein and initiates the most common form of human AML. Here(More)
There is an error in the representation of white blood cell counts in Fig 7B. Specifically, the Y-axis label states the data is expressed as ³x10 12 /L² but the correct values should be expressed as ³x10 9 /L². The red blood cell counts and platelet count data in the rest of Fig 7B are correct. Please see the correct Fig 7 here. Copyright: © 2016 Draper et(More)
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