Olga Tikhobrazova

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Dynamic regulation of glycosylation of the neural cell adhesion molecule (NCAM) by an unusual large negatively charged polysialic acid (PSA) is the major prerequisite for correct formation of brain circuitries during development and for normal synaptic plasticity, learning and memory in the adult. Traditionally, PSA is viewed as a de-adhesive highly(More)
Heparan sulfate (HS) proteoglycans represent a major component of the extracellular matrix and are critical for brain development. However, their function in the mature brain remains to be characterized. Here, acute enzymatic digestion of HS side chains was used to uncover how HSs support hippocampal function in vitro and in vivo. We found that long-term(More)
The effectiveness of the developed combined drug as capsule and suspension dosage forms based on dimephosphone® (dimethyl 1,1-dimethyl-3-oxobutylphosphonate) and calcium carbonate was demonstrated for treatment and prophylaxis of bone diseases. According to IR spectra, dimephosphone® was chemisorbed to calcium ions on the surface of calcium carbonate to(More)
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