Olga Sonia León

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BACKGROUND The cyclooxygenase-2 inhibitor nimesulide is able to reduce kainate-induced oxidative stress in vivo. Here we investigate if this effect is mediated by the direct antioxidant properties of nimesulide using a well-characterized in vitro model of kainate toxicity. RESULTS Exposure of rat brain homogenates to kainate (12 mM) caused a significant(More)
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