Olga Sakharova

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We present the case of a 54-year-old woman who underwent right adrenalectomy for palliation of Cushing's symptoms. She had recently been diagnosed with lung adenocarcinoma. Pathologic findings revealed a 5 cm adrenal adenoma with a metastatic adenocarcinoma deposit. The occurrence of tumor-to-tumor metastasis is rare, and the finding of a metastasis within(More)
The tetanus toxin (TT) action on crude glutamic acid decarboxylase (GAD) preparation and GAD activity of synaptosomes were studied. TT was not found to affect GAD, but the GAD activity of synaptosomes isolated from the rat brain cortex increased by 46% after 15 min of incubation in the presence of a dose of 0.1 DLM TT. In some experiments, the GAD activity(More)
A study was made of the effect of tetanus toxin (TT) in doses of 20-1000 MLD (for rats) on synaptosomes isolated from the rat brain cortex. TT produced a decrease in K+ content in synaptosomes. The effect depended on the dose of TT (I50=22 MLD). The content of Na+ remained unchanged. The action of TT depended on the time and the maximal effect was seen upon(More)
Synaptosomes isolated from the rat brain cortex were made use of to study the effect of tetanus toxin (TT) in doses of 1000-1200 MTD/ml (for rats) on 3H-GABA uptake and GABA and 3H-GABA release. After 15 minutes of incubating synaptosomes with TT, partial suppression of 3H-GABA release induced by K+-depolarization (30 and 40 mMK+) was discovered. TT did not(More)
Activity of Na, K -ATPase, acetylcholinesterase (AChE) and glutamic acid decarboxylase (GAD) in the fractions of the rat brain and spinal cord tissue were studied in rats during a single electroshock (ES) and 5 and 30 minutes after it. GAD activity of the synaptosome fraction was shown to decrease insignificantly, but activity of AChE, Na, K -ATPase and(More)
As shown by the method of electrophoresis on polyacrylamide gel, the number of proteins with low electrophoretic mobility proved to be increased in the triton extract fractions of synaptic structures isolated from spinal cord of rats with local tetanus; no changes in the protein spectrum were revealed in the dodecyl-sulphate extract. In vitro tetanus toxin(More)
A study was made of the functional potentialities of synaptosomes isolated from the brain cortex and lumbar enlargement of the spinal cord. The yield of synaptosomes from the brain cortex amounted to 10 mg (with reference to protein) from 1 g of wet tissue, and that of synaptosomes from the spinal cord was equal to 1/3 of the yield from the brain, with the(More)
The effect of electrical stimulation on the membrane-bound tyrosine hydroxylasectivity of the rat hypothalamus synaptosomes was studied. The electrical stimulation caused an elevation of O2 consumption and the elevation of glycolysis indicating synaptosome excitation. The membrane-bound tyrosine hydroxylase activity increased under these conditions. The KM(More)
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