Olga Pudova

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The quaternisation of N-substituted benzimidazoles by heating with various alkyl, allyl, propargyl and benzyl chlorides and bromides leads to the formation of benzimidazolinium salts. The interaction of N-monosubstituted benzimidazoles with various salts (CuCl2, ZnCl2, CoCl2, PdCl2 and AgNO3) yielded stable solid complexes. Potential cytotoxic activity of(More)
The regioselective synthesis of fluorescent oligothiophene isothiocyanates is described. The isothiocyanates were reacted with bovine serum albumin (BSA) following standard procedures and the optical properties of the oligothiophene-BSA conjugates were analyzed as a function of oligomer concentration, time, and irradiation power. The oligothiophene-BSA(More)
The efficiency of the key classes of disinfecting and decontaminating chemicals, used to eliminate a biological contamination of the human habitat, was analyzed in the paper. It is underlined that, should any biological agents with unknown properties (biological terror, military threat) be detected, it is advisable to choose the ecologically less hazardous(More)
The problems of biological protection of the general population and military staff against biological hazard sources, primarily against biological terrorism and military threat underlie works on the design of new disinfectants having a universal spectrum of antimicrobial action and less ecological hazard than currently available ones. Elimination of(More)
Organoammonium hydroselenites were synthesized and investigated as potential selective, anticancer prodrugs. These compounds were studied in vitro on human fibrosarcoma (HT-1080), hamster kidney endothelial (BHK 21) and normal mouse embryonic fibroblasts (NIH 3T3). Most of them were very active against HT-1080 (0.6-5.3 g/ml). Amino acid hydroselenites(More)
The [2+3] dipolar cycloaddition of nitrile oxides to the double C = C bonds of thiophene-1, 1-dioxides leads to formation of the fused isoxazolines-2 (1, 2). Tumor growth inhibition of these compounds strongly depends on the nature of group IV A element increasing from slightly active tert-butyl derivatives to silicon and germanium containing analogues. The(More)
The authors analyzed the experience of disinfection experts related with the designing of new disinfection chemicals and of their composition variations. The key regularities were defined, which are important for the designing of effective disinfectants with preset properties capable of rapidly and safely inactivating a microbe contamination of different(More)
The researchers compared the main microbiological characteristics of some Bacillus antracoides strains after their cultivation in different nutrient media. The study found that the growth and sporification rate, R-S dissociation ability, and sensitivity to disinfectants are strain properties and significantly depend on the composition of the nutrient medium.
Ecological requirements to reduce negative effects of chemical disinfectants were one on major determinants the line of works to develop and introduce novel compounds that are environmentally safe hydrogen peroxide derivatives. The paper analyzes the possible routes of entering different fluorine compounds into the environment when disinfecting measures are(More)
The article contains the results of the test of PFK-M composition bactericidal activity against a range of extremely dangerous infective pathogens. The preparation proved to be highly effective for the disinfection of surfaces, sanitary and technical equipment, linen, dishes, and medical utensils contaminated by plague, cholera, and anthrax pathogens. The(More)