Olga Orlova

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The aim of this study was to evaluate the efficacy and safety of intramuscular (IM) administration of botulinum toxin type A (Dysport((R)), Ipsen Biopharm Ltd.) for the treatment of cervical dystonia (CD) and the long-term safety and efficacy of repeated treatments. During the randomized, double-blind, placebo-controlled phase patients were randomized to(More)
Here we examined the mechanism of propagation of variation potential (VP) induced by burning in wheat leaves. Participation of hydraulic and chemical mechanisms in VP transmission was analyzed by optical coherent tomography and a radioactive tracer method, respectively. The speed of the hydraulic signal considerably exceeded the VP velocity. Investigation(More)
A special group of substances that are very dangerous for the biosphere includes war gases such as mustard gas (bis(2-chloroethyl)sulphide). The influence of mustard gas hydrolysis products (MGHPs) on soil microbiota has been investigated. These substances bear numerous toxic effects on soil microorganisms. They change significantly the number and the(More)
This article summarizes the results obtained during the laboratory and pilot development of integrated biologic and physicochemical treatment and reuse of diluted pig manure streams. The application of a straw filter was an effective means to separate the solid and liquid fractions of raw wastewater and resulted in the removal of a significant part of the(More)
Treatment of dystonias is generally symptomatic. To produce sufficient therapy effects, therefore, frequently a multimodal and interdisciplinary therapeutic approach becomes necessary, combining botulinum toxin therapy, deep brain stimulation, oral antidystonic drugs, adjuvant drugs and rehabilitation therapy including physiotherapy, occupational therapy,(More)
BACKGROUND Cytology-based screening has significantly decreased incidence of and mortality from cervical cancer. High sensitivity of high-risk human papillomavirus (hrHPV) test for the detection of high-grade cervical intraepithelial neoplasia (CIN) makes it a useful screening tool, especially in settings where cytology is not available or not quality(More)
In this paper, we generalize the notion of Kantorovich-type sampling operators using the Fejér-type singular integral. By means of these operators we are able to reconstruct signals (functions) which are not necessarily continuous. Moreover, our generalization allows us to take the measurement error into account. The goal of this paper is to(More)
The article discusses the pool of signaling molecules that regulate the functional activity of the skin cells. Molecules of apoptosis and cells skin aging are p53, p21, p15, Cdk 4/6 and Bcl-2. Inflammation in skin fibroblasts are realized through the cytokines TNF-α, TGF-β, IL-1, ICAM-1, matrix metalloproteinase MMP-1,2,3,9, transcription factor NF-κB and(More)
Combined biological and physico-chemical treatment of filtered pig manure wastewater has been investigated on the pilot installation operated under ambient temperatures (15-20 degrees C) and included: i) UASB-reactor for elimination of major part of COD from the filtrate; (ii) stripper of CO2 + fluidised bed crystallisator for phosphate (and partially(More)