Olga Ksenofontova

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A novel chemical platform based on branched piperazine-2,5-dione derivatives (2,5-diketopiperazines) for creating orally available biologically active peptidomimetics has been developed. The platform includes a diketopiperazine scaffold with "built-in" functionally active peptide fragments covalently attached via linkers. The concept was applied to two(More)
A comparative analysis of the two most widely used water models, SPC/E and TIP4P, was carried out. The applicability of the models for studying the conformational mobility of peptides of the insulin superfamily, including proinsulin and insulin-like growth factors (IGF1 and IGF2), was assessed. It was demonstrated that, in the case of both water models, the(More)
The goal of the work was to perform by the method of molecular dynamics a comparative analysis of conformational mobility of evolutionary related peptides—insulin, proinsulin, IGF1, and IGF2. The proinsulin molecule has been shown to have the highest mobility, whereas IGF1—the lowest. Rotation radius (Rg) of insulin, IGF1, and IGF2 changes insignificantly,(More)
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