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Sulfhydryl-mediated redox signaling in inflammation: role in neurodegenerative diseases
Posttranslational modifications of cysteine sulfhydryl (–SH) moieties, e.g., S-nitrosylation, S-glutathionylation, or S-sulfuration, play an important role in cellular response to oxidative stress.… Expand
Upregulation of Glutaredoxin-1 Activates Microglia and Promotes Neurodegeneration: Implications for Parkinson's Disease.
- Olga Gorelenkova Miller, Jessica B Behring, +5 authors J. Mieyal
- Biology, Medicine
- Antioxidants & redox signaling
- 20 December 2016
AIMS Neuroinflammation and redox dysfunction are recognized factors in Parkinson's disease (PD) pathogenesis, and diabetes is implicated as a potentially predisposing condition. Remarkably,… Expand
Novel chloroacetamido compound CWR-J02 is an anti-inflammatory glutaredoxin-1 inhibitor
- Olga Gorelenkova Miller, Kyle S. Cole, +6 authors J. Mieyal
- Chemistry, Medicine
- PloS one
- 20 November 2017
Glutaredoxin (Grx1) is a ubiquitously expressed thiol-disulfide oxidoreductase that specifically catalyzes reduction of S-glutathionylated substrates. Grx1 is known to be a key regulator of… Expand
Critical Roles of Glutaredoxin in Brain Cells-Implications for Parkinson's Disease.
SIGNIFICANCE Glutaredoxin (Grx)1, an evolutionarily conserved and ubiquitous enzyme, regulates redox signal transduction and protein redox homeostasis by catalyzing reversible S-glutathionylation.… Expand
Reply to the Commentary “To Gorelenkova Miller and Mieyal (2015): Sulfhydryl-mediated redox signaling in inflammation: role in neurodegenerative diseases” by M. Kato
S-glutathionylation) that are particularly relevant to cell signaling. Since interand intramolecular disulfides and glutathionyl mixed disulfides are known to be reductively reversed by the… Expand