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  • Galina F. Makhaeva, Elena V Rudakova, +5 authors Rudy J. Richardson
  • Chemistry, Medicine
  • Journal of applied toxicology : JAT
  • 2014 (First Published: 1 December 2014)
  • Inhibition and aging of neuropathy target esterase (NTE) by neuropathic organophosphorus (OP) compounds triggers OP compound-induced delayed neuropathy (OPIDN), whereas inhibition ofContinue Reading
  • Galina F. Makhaeva, Alexey Yu. Aksinenko, Vladimir B. Sokolov, Olga G. Serebryakova, Rudy J. Richardson
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry letters
  • 2009 (First Published: 1 October 2009)
  • Acetylcholinesterase and butyrylcholinesterase inhibitors are potential cognition enhancers in Alzheimer disease. O,O-Dialkylphosphate inhibitors with 1-substituted 2,2,2-trifluoroethoxy leavingContinue Reading
  • Galina F. Makhaeva, Olga G. Serebryakova, +4 authors Iu. V. Martynov
  • Biology, Medicine
  • Doklady Biochemistry and Biophysics
  • 2008 (First Published: 1 December 2008)
  • 352 Organophosphorous compounds (OPCs) are widely used not only in agrochemical practice but are also cited in pharmacopoeias of many countries as drugs for treating schistosomiasis, glaucoma, andContinue Reading
  • Galina F. Makhaeva, Sofya V Lushchekina, +8 authors Sergey O. Bachurin
  • Chemistry, Medicine
  • Scientific reports
  • 2015 (First Published: 1 October 2015)
  • Alzheimer disease is a multifactorial pathology and the development of new multitarget neuroprotective drugs is promising and attractive. We synthesized a group of original compounds, which combineContinue Reading
  • Nadezhda Sokolova, Valentine G Nenajdenko, Vladimir B. Sokolov, Olga G. Serebryakova, Galina F. Makhaeva
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry letters
  • 2011 (First Published: 1 December 2011)
  • A modification of novel fluorinated organophosphorous compounds containing terminal alkyne group by different azidopeptides via Cu(I)-catalyzed click chemistry has been described. The inhibitorContinue Reading
  • Galina F. Makhaeva, Natalia P. Boltneva, +7 authors Rudy J. Richardson
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry
  • 2016 (First Published: 1 March 2016)
  • A series of 31 N,N-disubstituted 2-amino-5-halomethyl-2-thiazolines was designed, synthesized, and evaluated for inhibitory potential against acetylcholinesterase (AChE), butyrylcholinesterase (BChE)Continue Reading
  • Galina F. Makhaeva, Sofya V Lushchekina, +8 authors Rudy J. Richardson
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry
  • 2017 (First Published: 1 November 2017)
  • We investigated the inhibitory activity of 4 groups of novel acridine derivatives against acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and carboxylesterase (CaE) using the methods ofContinue Reading
  • Evgeny V Shchegol'kov, Galina F. Makhaeva, +9 authors Rudy J. Richardson
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry
  • 2017 (First Published: 1 August 2017)
  • To search for effective and selective inhibitors of carboxylesterase (CaE), a series of 7-hydroxy-7-polyfluoroalkyl-4,7-dihydroazolo[5,1-c][1,2,4]triazines has been synthesized. Their inhibitoryContinue Reading